Results of a multicenter trial "Epidemiology of Gastroesophageal Reflux Disease in Russia" (MEGRE)


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Abstract

Aim. To assess prevalence of gastroesophageal reflux disease (GERD) in Russia in MEGRE trial in 6 cities of the Russian Federatiion (Kazan, Kemerovo, Krasnoyarsk, Ryazan, St-Petersburg, Saransk).
Material and methods. Mayo Clinic questionnaire (USA) adapted for Russia was used to question 7812 people over 18 years of age from of random population sample. The symptoms (heartburn and regurgitation) were classified as frequent if they arose once a week and more often for the last 12 months, rare symptoms arose less often than once a week. The responders with frequent heartburn and/or regurgitation were regarded as persons with epidemiological quantitative criteria of GERD.
Results. Heartburn occurred in 47.5% responders: frequent in 9%, rare in 38.5%. Regurgitation occurred in 42.9%: frequent in 7.6%, rare in 35.3%. GERD prevalence was 13.3% (city range 11.3-14.3%). Frequent GERD symptoms are associated with frequent gaseous eructation (24.3%), chronic cough (22.9%), chest pain (15.1%), dysphonia (11.4%.). To stop heartburn, 88% responders took antacids, 32% - blockers of histamine H2-receptors and only 23% - inhibitors of proton pump. Only 52.8% responders with frequent chest pain and 29.3% those with frequent hearburn visited a doctor.
Conclusion. The population-based trial MEGRE conducted by international methodology in 6 cities of Russia demonstrated that GERD prevalence is 13.3%. Most of the patients pay little attention to the symptoms, do not seek medical advice and, therefore, receive no adequate treatment.

About the authors

Leonid Borisovich Lazebnik

Antonina Aleksandrovna Masharova

Email: a.masharova@gmail.com

Dmitriy Stanislavovich Bordin

Email: dbordin@mail.ru

Yuriy Vasil'evich Vasil'ev

Email: gastroenter@rambler.ru

Evgeniy Ivanovich Tkachenko

Email: tkachenkoe @mail.ru

Rustem Abbasovich Abdulkhakov

Email: rustemabdul@mail.ru

Mikhail Aleksandrovich Butov

Email: butov-m@yandex.ru

Elena Yur'evna Eremina

Email: eeu61@mail.ru

Lyudmila Ivanovna Zinchuk

Email: gospitter@yandex.ru

Vladislav Vladimirovich Tsukanov

Email: rsimpn@scn.ru

L B Lazebnik

Central Research Gastroenterological Institute, Moscow

Central Research Gastroenterological Institute, Moscow

A A Masharova

Central Research Gastroenterological Institute, Moscow

Central Research Gastroenterological Institute, Moscow

D S Bordin

Central Research Gastroenterological Institute, Moscow

Central Research Gastroenterological Institute, Moscow

Yu V Vasiliev

Central Research Gastroenterological Institute, Moscow

Central Research Gastroenterological Institute, Moscow

E I Tkachenko

I.I. Mechnikov St-Petersburg State medical Academy

I.I. Mechnikov St-Petersburg State medical Academy

R A Abdulkhakov

State Medical University, Kazan

State Medical University, Kazan

M A Butov

I.P. Pavlov State Medical University, Ryazan

I.P. Pavlov State Medical University, Ryazan

E Yu Eremina

N.P. Ogarev Mordovian State University, Saransk

N.P. Ogarev Mordovian State University, Saransk

L I Zinchuk

State Medical Academy, Kemerovo

State Medical Academy, Kemerovo

V V Tsukanov

Research Institute of North Medical Problems of the Russian Academy of Medical Sciences, Krasnoyarsk

Research Institute of North Medical Problems of the Russian Academy of Medical Sciences, Krasnoyarsk

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Copyright (c) 2011 Lazebnik L.B., Masharova A.A., Bordin D.S., Vasil'ev Y.V., Tkachenko E.I., Abdulkhakov R.A., Butov M.A., Eremina E.Y., Zinchuk L.I., Tsukanov V.V., Lazebnik L.B., Masharova A.A., Bordin D.S., Vasiliev Y.V., Tkachenko E.I., Abdulkhakov R.A., Butov M.A., Eremina E.Y., Zinchuk L.I., Tsukanov V.V.

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