Cardiovascular diseases and erectile dysfunction


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Abstract

Until recently, erectile dysfunction (ED) has been considered to be psychogenic in nature in most cases. Advances in our knowledge about the physiology of erection and the pathophysiology of ED have clarified that it is due to organic causes in most cases. Atherosclerosis-associated intraorgan lesion is most frequently encountered.
ED is closely related to common cardiovascular risk factors, such as diabetes mellitus, arterial hypertension, dyslipidemia, smoking, physical inactivity. Endothelial dysfunction is of great and universal importance for the genesis of cardiovascular diseases (CVD) and ED. As a manifestation of endothelial dysfunction, ED is an independent risk factor for CVD since vascular endothelial damage is one of the first stages of atherosclerotic plaque formation. ED is an early symptom that is suggestive of atherosclerotic lesion of arterial vessels, coronary arteries in particular. The first manifestation of atherosclerosis in the large arteries is frequently the life-threatening complications myocardial infarction or stroke, which underlines the importance of timely detection of early-stage vascular system lesions.
Understanding ED of arteriogenic origin as an early sign of vascular lesion gives a clinician the unique chance to take preventive measures that can prevent complications of CVD.

References

  1. Feldman H. A., Goldstein I., Hatzichristou D. G. et al. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J. Urol. (Baltimore) 1994; 151: 54-61.
  2. Мазо Е. Б., Гамидов С. И., Овчинников Р. И. и др. Этиология, патогенез, диагностика и лечение эректильной функции у пожилых. Фарматека 2006; 8 (123): 31-35.
  3. Минаков Э. В., Хохлов Р. А., Кузнецова Т. Н. и др. Факторы риска эректильной дисфункции у пациентов с сердечно-сосудистыми заболеваниями. Рационал. фармакотер. в кардиол. 2009; 3: 25-30.
  4. Tikkanen M. J., Jackson G., Tammela T. et al. Erectile dysfunction as a risk factor for coronary heart disease: implications for prevention. Int. J. Clin. Pract. 2007; 61 (2): 265- 268.
  5. Пушкарь Д. Ю., Верткин А. Л. Эректильная дисфункция: кардиологические аспекты. М.: Мед-пресс-информ; 2005.
  6. Лу Т. Нарушения половой функции у мужчин. Урология по Дональду Смиту. М.: Практика; 2004.
  7. Bohm M., Baumhakel M., Jeffrey L. Sexual function, satisfaction, and association of erectile dysfunction with cardiovascular disease and risk factors in cardiovascular high-risk patients: Substudy of the ONgoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNT Study in ACE-INtolerant Subjects with Cardiovascular Disease (Ontarget/Transcend). Am. Heart J. 2007; 154 (1): 94-101.
  8. Fung M. M., Bettencourt R., Barrett-Connor E. Heart disease risk factors predict erectile dysfunction 25 years later: the Rancho Bernardo Study. J. Am. Coll. Cardiol. 2004; 43 (8): 1405-1411.
  9. Mirone V., Ricci E., Gentile V. et al. Determinants of erectile dysfunction risk in a large series of Italian men attending andrology clinics. Eur. Urol. 2004; 1 (1): 87-91.
  10. Solomon H., Man J. W., Jackson G. Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. Heart 2003; 89: 251-253.
  11. Kaiser D. R., Billups K., Mason C. et al. Impaired brachial artery endothelium-dependent and independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease. J. Am. Coll. Cardiol. 2004; 43 (2): 179-184.
  12. Bocchio M., Desideri G., Scarpelli P. et al. Endothelial cell activation in men with erectile dysfunction without cardiovascular risk factors and overt vascular damage. J. Urol. (Baltimore) 2004; 171 (4): 1601-1604.
  13. Roumeguere T., Wespes E., Carpentier Y. et al. Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk. Eur. Urol. 2003; 44 (3): 355-359.
  14. Мазо Е. Б., Гамидов С. И., Андранович С. В. и др. Возможности предположительной диагностики артериогенной эректильной дисфункции врачами первого звена. Тер. арх. 2006; 10: 24-28.
  15. Solomon H., Man J., Wierzbicki A. S. et al. Erectile dysfunction: cardiovascular risk and the role of the cardiologist. Int. J. Clin. Pract. 2003; 57 (2): 96-99.
  16. Vlachopoulos C., Rokkas K., Ioakeimidis N. et al. Prevalence of asymptomatic coronary artery disease in men with vasculogenic erectile dysfunction: a prospective angiographic study. Eur. Urol. 2005; 48: 996-1002.
  17. Kim S. W., Paick J., Park D. W. et al. Potential predictors of asymptomatic ischemic heart disease in patients with vasculogenic erectile dysfunction. Urology 2001; 58 (3): 441-445.
  18. Pritzker M. R. The penile stress test: a window to the hearts of man? Circulation 1999; 100 (Suppl. 1): 1-711.
  19. Kaya C., Uslu Z., Karaman I. Is endothelial function impaired in erectile dysfunction patients? Int. J. Impot. Res. 2006; 18: 55-60.
  20. Хирманов В. Н. Эректильная дисфункция у больных сердечно-сосудистыми заболеваниями: от выяснения причин к лекарственной коррекции. Фарматека 2004; 14: 26- 31.
  21. Хирманов В. Н. Эректильная дисфункция и сердечно-сосудистый континуум. Фарматека 2005; 13: 84-89.
  22. O'Kane P. D., Jackson G. Erectile dysfunction, is there silent obstructive coronary artery disease? Int. J. Clin. Pract. 2001; 55: 219-220.
  23. Billups K. L., Bank A. J., Padma-Nathan H. et al. Erectile dysfunction is a marker for cardiovascular disease: results of the minority health institute expert advisory panel. J. Sex. Med. 2005; 2: 40-52.
  24. Rodriguez J. J., Al Dashti R., Schwarz E. R. Linking erectile dysfunction and coronary artery disease. Int. J. Impot. Res. 2005; 17: S12-S18.
  25. Бакшеев В. И., Коломоец Н. М., Гончарук А. И. Синдром эректильной дисфункции в практике терапевта. Клин. мед. 2005; 3: 16-23.
  26. Persson G. Five-year mortality in a 70-year-old urban population in relation to psychiatric diagnosis, personality, sexuality and early parental death. Acta Psychiatr. Scand. 1981; 64: 244-253.
  27. Smith D. G., Frankel S., Yamell J. Sex and death: are they related? Findings from the Caterphilly Cohort Study. Br. Med. J. 1997; 315: 1641-1644.
  28. Ефремов Е. А., Дорофеев С. Д. Медикаментозная терапия эректильной дисфункции. Рус. мед. журн. 2003; 11 (24): 1373-1340.
  29. Карпов Ю. А. Лечение эректильной дисфункции у больных с сердечно-сосудистыми заболеваниями: от обсуждения безопасности к потенциально благоприятным эффектам. Кардиология 2004; 1: 83-87.
  30. Bocchi E. A., Guimares G., Mocelin A. et al. Sildenafil effects on exercise, neurohormonal activation, and erectile dysfunction in congestive heart failure. A double-blind, placebo-controlled, randomized study followed by a prospective treatment for erectile dysfunction. Circulation 2002; 106 (9): 1097-1103.
  31. Kostis J. B., Jackson G., Rosen R. Sexual dysfunction and cardiac risk (the Second Princeton consensus conference). Am. J. Cardiol. 2005; 96 (2): 313-321.

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