The first experience in using rituximab in Mikulicz's disease


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Abstract

The paper describes a case of Mikulicz's disease (MD) in a young woman (aged 19 years) with symmetrical large salivary gland lesion concurrent with the enlarged lacrimal glands. Immunomorphological and molecular studies of parotid gland biopsy specimens revealed the formation of MALT tissue without signs of B-cell clonality of an infiltrate. The diagnosis of lacrimal sac lymphoma was ruled out. MD was diagnosed. The use of rituximab in therapy for MD has first demonstrated a positive result in Russian and worldwide practice.

About the authors

V I Vasilyev

Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow

Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow

S G Palshina

Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow

Email: vitalana@mail.ru
Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow

M V Simonova

Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow

Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow

O A Logvinenko

Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow

Email: oksanalogw@hotmail.ru
Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow

S Kh Sedyshev

Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow

Email: sedishev@mail.ru
Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow

B V Mitrikov

Moscow State University of Dentistry and Medicine

Email: batom@yandex.ru
Moscow State University of Dentistry and Medicine

N A Probatova

N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences

N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences

N V Kokosadze

N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences

N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences

T N Safonova

Institute of Eye Diseases, Russian Academy of Medical Sciences, Moscow

Institute of Eye Diseases, Russian Academy of Medical Sciences, Moscow

E N Aleksandrova

Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow

Email: irramnlab@rambler.ru
Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow

E L Nasonov

Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow

Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow

References

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