Email this article Effect of TT genotype of the vitamin D receptor gene on bone mineral density in dialysis patients
- Authors: Shishkin AN1, Mazurenko SO1, Aseyev MV2
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Affiliations:
- Saint Petersburg University
- D. O. Ott State Institute of Obstetrics and Gynecology
- Issue: Vol 82, No 6 (2010)
- Pages: 39-43
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30612
- ID: 30612
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Abstract
Subjects and methods. Eighty-two patients treated with long-term hemodialysis were examined. Along with physical examination, osteodensitometry was carried out and VDR gene polymorphism was studied in all the patients.
Results. OP in the study skeletal parts was more common in the TT-genotype group. The serum concentration of intact parathyroid hormone and the activity of alkaline phosphatase were also higher in the TT-genotype group. However, the differences were statistically insignificant between the TT-, Tt-, and tt- genotype groups. BMD was lowest in each study skeletal parts in the TT-genotype group and this difference was statistically significant in the proximal femur, which was estimated by the Z index (p = 0.02).
Conclusion. The results of the present study confirm the hypothesis that the VRD gene is a genetic determinant of bone metabolism in patients with chronic renal disease who receive long-term hemodialysis.
About the authors
A N Shishkin
Saint Petersburg University
Email: alexchishkin@bk.ru
Кафедра терапии медицинского факультетад-р мед. наук, проф., зав; Санкт-Петербургский университет; Saint Petersburg University
S O Mazurenko
Saint Petersburg University
Email: dr mazurenko@mail.ru
Кафедра терапии медицинского факультетаканд. мед. наук, доц; Санкт-Петербургский университет; Saint Petersburg University
M V Aseyev
D. O. Ott State Institute of Obstetrics and Gynecology
Email: micas@mail.ru
лаборатория перинатальной диагностикиканд. биол. наук, ст. науч. сотр; Государственный институт акушерства и гинекологии им. Д. О. Отта РАМН; D. O. Ott State Institute of Obstetrics and Gynecology
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