Prolonged bone marrow aplasias in patients with acute leukemias after chemotherapy


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Abstract

Aim. To analyze the causes of prolonged hematopoietic tissue aplasias in patients with acute leukemias (AL) after chemotherapy courses.
Materials and methods. Data on 7 patients with acute myeloid leukemia, followed up at the Hematology Departments, Hematology Research Center, Russian Academy of Medical Sciences, over the period 2003 to 2007, who had developed deep bone marrow aplasia (BMA) inadequate to cytostatic drug exposure during chemotherapy, were analyzed. The authors compared in all the patients the values of peripheral blood and bone marrow (BM) puncture specimens and the results of blood tests using the polymerase chain reaction at different AL development stages with the results of an immunohistochemical study using the markers of viruses of hepatitis C and B, a herpes group (EBV, CMV, HSV-1, HSV-2) and parvovirus B19.
Results. The marker of hepatitis C was detected in 6 of the 7 patients with prolonged BMA; 3 of these 6 patients showed a simultaneous infection with hepatitis B. Six of the 7 patients were found to have concomitant BM lesion with various herpes group viruses. Two patients had a resistant form of AL.
Conclusion. Hepatitis C virus infection in patients and the resistant form of the disease were the principal causes of the development of BMA inadequate to cytostatic drug exposure. Affliction of abundant bone marrow cells with herpes group viruses was not a direct cause, but might substantially aggravate BMA.

About the authors

N V Gaidamaka

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Email: nadya314@yandex.ru
Hematology Research Center, Russian Academy of Medical Sciences, Moscow

E N Parovichnikova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Email: elenap@blood.ru
Hematology Research Center, Russian Academy of Medical Sciences, Moscow

L E Zavalishina

P. A. Herzen Moscow Oncology Research Institute

P. A. Herzen Moscow Oncology Research Institute

T Ts Garmayeva

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Email: garmaeva@yandex.ru
Hematology Research Center, Russian Academy of Medical Sciences, Moscow

T V Gaponova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

V V Troitskaya

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

O S Pokrovskaya

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

D S Tikhomirov

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

E E Khodunova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

D S Maryin

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

I B Kaplanskaya

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

E N Ustinova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

E A Mikhailova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

V G Isayev

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

E O Gribanova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

V G Savchenko

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

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Copyright (c) 2010 Gaidamaka N.V., Parovichnikova E.N., Zavalishina L.E., Garmayeva T.T., Gaponova T.V., Troitskaya V.V., Pokrovskaya O.S., Tikhomirov D.S., Khodunova E.E., Maryin D.S., Kaplanskaya I.B., Ustinova E.N., Mikhailova E.A., Isayev V.G., Gribanova E.O., Savchenko V.G.

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