Email this article The clinical diagnostic value of a study of the activity of enzymes of the guanyl branch of purine metabolism in patients with ankylosing spondyloarthritis
- Authors: Zborovskiy A.B.1, Mozgovaya E.E.1, Martem'yanov V.F.1, Slyusar' O.P.1, Stazharov M.Y.1, Bedina SA1, Zborovsky AB2, Mozgovaya EE2, Martemyanov VF2, Slyusar OP3, Stazharov MY.2, Bedina SA2
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Affiliations:
- Research Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical Sciences
- City Clinical Hospital Twenty Five
- Issue: Vol 82, No 4 (2010)
- Pages: 48-52
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30591
- ID: 30591
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Abstract
Materials and methods. The serum activities of the PM enzymes: xanthine oxidase (XO), guanine deaminase (GDA), guanosine deaminase (GSDA), purine nucleoside phosphorylase (PNP), guanosine phosphorylase (GP), and adenosine deaminase (ADA) were determined in 55 patients (51 males and 4 females) aged 36.0 ± 1.4 years). A control group comprised 30 apparently age- and gender-matched healthy individuals, as in the study group.
Results. On admission, the patients were found to have increased XO, GDA, PNP, and GD activities and decreased GSDA activity. The higher activity of the process was observed, the greater activities of GDA, XO, PNP, GP and the lower activity of GSDA and ADA were. There were the enzymatic activity differences that depended on the degree of pathological process activity, clinical form, the magnitude of X-ray changes, and the degree of joint functional insufficiency.
Conclusion. The findings suggest that there may be PM disturbances in the immunocompetent cells.
About the authors
Aleksandr Borisovich Zborovskiy
Email: alena@vistcom.ru
Elena Eduardovna Mozgovaya
Email: alena@vistcom.ru
Vladislav Fedorovich Martem'yanov
Ol'ga Petrovna Slyusar'
Email: alena@vistcom.ru
Mikhail Yur'evich Stazharov
S A Bedina
A B Zborovsky
Research Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical SciencesResearch Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical Sciences
E E Mozgovaya
Research Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical SciencesResearch Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical Sciences
V F Martemyanov
Research Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical SciencesResearch Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical Sciences
O P Slyusar
City Clinical Hospital Twenty FiveCity Clinical Hospital Twenty Five
M Yu Stazharov
Research Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical SciencesResearch Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical Sciences
S A Bedina
Research Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical SciencesResearch Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical Sciences
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