Email this article The parameters of the blood prooxidant and antioxidant systems in bacterial and viral pneumonias
- Authors: Nagoev B.S.1, Ivanova Z.O.1, Nagoyev BS1, Ivanova ZO1
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- Issue: Vol 82, No 3 (2010)
- Pages: 38-42
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30556
- ID: 30556
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Abstract
Aim. To determine the level of malondialdehyde (MDA) in plasma and nitro blue tetrasolium in leukocytes as parameters of the blood prooxidant system and the activity of ceruloplasmin (CP) in serum and erythrocyte catalase as the parameters of antioxidant activity in bacterial and viral pneumonias.
Subjects and methods. The blood prooxidant and antioxidant systems were studied in 177 patients with bacterial and viral pneumonia over time.
Results. Heterodirectional changes were found in the parameters of the blood prooxidant and antioxidant systems in bacterial and viral pneumonias. There was a regular and significant increase in MDA levels, spontaneous HCT test, and erythrocyte catalase. At the same tine, CP activity depending on the etiology, stage, and degree of the disease was inhibited.
Conclusion. Severe prolonged impairments in the activity of the prooxidant and antioxidant systems and changes in their parameters are indicative of the more severe course of the disease, the presence of complications and infectious-inflammatory concomitant diseases.
Subjects and methods. The blood prooxidant and antioxidant systems were studied in 177 patients with bacterial and viral pneumonia over time.
Results. Heterodirectional changes were found in the parameters of the blood prooxidant and antioxidant systems in bacterial and viral pneumonias. There was a regular and significant increase in MDA levels, spontaneous HCT test, and erythrocyte catalase. At the same tine, CP activity depending on the etiology, stage, and degree of the disease was inhibited.
Conclusion. Severe prolonged impairments in the activity of the prooxidant and antioxidant systems and changes in their parameters are indicative of the more severe course of the disease, the presence of complications and infectious-inflammatory concomitant diseases.
References
- Akaike T. Role of free radicals in viral pathogenesis and mutation. Rev. Med. Viral 2001; 11(2): 87-101.
- Логинов А. С., Матюшин Б. М. Клиническое значение ферментной системы утилизации активных форм кислорода при хронических заболеваниях печени. Тер. арх. 1994; 66(4): 65-68.
- Владимиров Ю. А. Вестн. РАМН. 1998; 3: 43-51.
- Bast A., Haenen G. R. M. M., Doelman C. J. A. Oxidants and antioxidants: state of the art. Am. J. Med. 1991; 91(suppl. 30): 29-135.
- Ломакин М. С. Иммунобиологический надзор. М.: Медицина; 1990.
- Akerboom T. P. M., Gartner M., Sies H. Cellulare hyperoxide metabolism the role of glutation pyroxidases and catalase in liver. Bull. Eur. Physiopathol. Res. 1981; 17(suppl.): 221-227.
- Shonbaum G. R., Chance B. Catalase. In: The enzymes. New York; 1976; vol. 8: 363-408.
- Babior B. M. Oxidants from phagocytes: agents of defense and destruction. Blood 1988; 64(5): 959-966.
- Park B. N., Fikrig S. M., Smuhwick E. M. Infection and nitroblue tetrasolium reduction by neutrophils: A diagnostic aid. Lancet 1968; 2(2): 532-534.
- Ushyama M., Michara M. Determination of malonaldehyde precursor in tissues. Anal. Biochem. 1978; 86(1): 271-278.
- Камышников В. С. Справочник по клинико-биохимической лабораторной диагностике. Минск: Беларусь; 2000; т. 1-2.
- Карпищенко А. И. Медицинская лабораторная диагностика. СПб.: Интермедика; 1999; т. 2.
- Stuart J., Gordon P. A., Lee T. R. Enzyme cytochemistry of blood and marrow cells. J. Histochem. 1975; 7(5): 471-487.
- Нагоев Б. С. Модификация цитохимического метода восстановления нитросинего тетразолия / Лаб. дело 1983; 8: 7-11.
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