Lower extremity deep vein thrombosis associated with gluten-sensitivity celiac disease


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Abstract

The paper describes a clinical case of gluten-sensitivity celiac disease (GSCD) and recurrent lower extremity vein thrombosis in a female patient. According to the data available in the literature, GSCD is associated with increased risk for thrombosis. Hyperhomocysteinemia and protein S, folates, and vitamin B12 deficiencies may be responsible for thrombophilia in GSCD. Moreover, GSCD may be associated with antiphospholipid syndrome.

References

  1. Saibeni S., Lecchi A. Prevalence of hyperhomocysteinemia in adult gluten-sensitive enteropathy at diagnosis: role of В12, folate, and genetics. Clin. Gastroenterol. Hepatol. 2005; 3 (6): 574-580.
  2. Saibeni S., Bottasso B., Spina L. et al. Assessment of thrombin-activatable fibrinolysis inhibitor (TAFI) plasma levels in inflammatory bowel diseases. Am. J. Gastroenterol. 2004; 99: 1966-1970.
  3. Marteau P., Cadranel J. F., Messing B. et al. Association of hepatic vein obstruction and coeliac disease in North African subjects. J. Hepatol. 1994; 20: 650-653.
  4. Ouakaa-Kchaou A., Ennaifer R. et al. Celiac disease associated with Budd-Chiari syndrome. Presse Med. 2008; 37 (2, pt 1): 239-241.
  5. McNeill A., Duthie F., Galloway D. J. Small bowel infarction in a patient with coeliac disease. J. Clm. Pathol. 2006; 59: 216- 218.
  6. Grigg A. P. Deep venous thrombosis as the presenting feature in a patient with coeliac disease and homocysteinaemia. Aust. N. Z. J. Med. 1999; 29 (4): 566-567.
  7. Zabana Y., Domenech E. et al. Celiac disease and cerebral thrombosis. Med. Clin. (Barc.) 2007; 129 (18): 718.
  8. Gabrielli M., Santoliquido A. Latent coeliac disease, hyperhomocysteinemia and pulmonary thromboembolism: a close link? Thromb. Haemost. 2003; 89 (1): 203-204.
  9. Khanna S., Chaudhary D. et al. Occult celiac disease presenting as splenic vein thrombosis. Indian J. Gastroenterol. 2008; 27 (1): 38-39.
  10. Azzam N. A., Al Ashgar H. et al. Mesenteric vein thrombosis as a presentation of subclinical celiac disease. Ann. Saudi Med. 2006; 26 (6): 471-473.
  11. Ludvigsson J. F., Welander A., Lassila R. et al. Risk of thromboembolism in 14,000 individuals with coeliac disease. Br. J. Haematol. 2007; 139 (1): 121-127.
  12. Kremer Hovinga J. A., Baerlocher G. et al. Deep venous thrombosis of the leg in acquired thrombophilia-hyperhomocysteinemia as a sequela of undetected celiac disease. Ther. Umsch. 1999; 56 (9): 519-522.
  13. Durlach J. Celiac disease, magnesium deficiency and venous thrombosis. Presse Med. 2001; 30 (18): 904.
  14. Kallel L., Matri S. et al. Deep venous thrombosis related to protein deficiency revealing celiac disease. Am. J. Gastroenterol. 2009; 104 (1): 256-257.
  15. Jorge О., Jorge A. et al. Celiac disease associated with antiphospholipid syndrome. Rev. Esp. Enferm. Dig. 2008; 100 (2): 102-103.
  16. Karoui S., Sfar S. et al. Antiphospholipid syndrome revealed by portal vein thrombosis in a patient with celiac disease. Rev. Med. Interne 2004; 25 (6): 471-473.

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