High-dose polychemotherapy of patients with poor-prognosis anaplastic T.0-large cell ALK+ lymphosarcoma
- Authors: Aitova L.G.1, Vinogradova Y.E.1, Kaplanskaya I.B.1, Lutsenko I.N.1, Zvonkov E.E.1, Momotyuk K.S.1, Kravchenko S.K.1, Kremenetskaya A.M.1, Vorob'ev A.I.1, Aitova LG1, Vinogradova Y.E1, Kaplanskaya IB1, Lutsenko IN1, Zvonkov EE1, Momotyuk KS1, Kravchenko SK1, Kremenetskaya AM1, Vorobyev AI1
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Affiliations:
- Issue: Vol 81, No 7 (2009)
- Pages: 53-57
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30393
- ID: 30393
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Full Text
Abstract
Material and methods. We treated 13 patients with stage III-IV ALCL ALK+. The age of the patients ranged from 17 to 44 years (median 26 years). The diagnosis was made using morphological, histological, immunohistochemical methods with application of monoclonal antibodies to CD30, ALK, CD3, CD4, CD8, CD7, CD34, CD15, CD68, CD20, CD45RO, CD45RA. The patients were treated according to the protocol NHL BFM-90. ASHC was made in two patients with the disease stage IV.
Results. We obtained a complete remission in 12 of 13 patients, one woman died of infectious complications in the beginning of the treatment, one man had early recurrence 45 days after the end of the treatment with lethal outcome and disease progression. Two patients at stage IV and poor prognosis had undergone ASHC transplantation. They are now in remission for 5 and 12 months.
Conclusion. ALCL ALK+ is characterized by an aggressive clinical course (11 of 13 patients had stage III-IV), high rate of extranodal lesions. Twelve patients achieved a complete remission, 11 (91.6%) of 12 patients are alive in observation median 27 months. We effectively used ASHC transplantation in the first-line treatment of 2 patients with stage IV of the disease and poor prognosis.
About the authors
Lidiya Gamilevna Aitova
Email: l.aitova@mail.ru
Yuliya Eykhenovna Vinogradova
Email: jvinogr@blood.ru
Irina Borisovna Kaplanskaya
Irina Nikolaevna Lutsenko
Email: lucenko@blood.ru
Evgeniy Evgen'evich Zvonkov
Email: zvonkov@blood.ru
Kira Sergeevna Momotyuk
Email: kira@blood.ru
Sergey Kirillovich Kravchenko
Email: krav@blood.ru
Aleksandra Mikhaylovna Kremenetskaya
Email: mtkalexandra@gmail.com
Andrey Ivanovich Vorob'ev
L G Aitova
Yu E Vinogradova
I B Kaplanskaya
I N Lutsenko
E E Zvonkov
K S Momotyuk
S K Kravchenko
A M Kremenetskaya
A I Vorobyev
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