Email this article Effects of recurrent herpetic infection on functional activity of T-cells in patients with rheumatoid arthritis
- Authors: Sviridova VS1, Kologrivova EN1, Pronina NA1, Eliseeva LV1, Naslednikova IO1, Sviridova VS1, Kologrivova EN1, Pronina NA1, Eliseeva LV1, Naslednikova IO1
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Affiliations:
- Issue: Vol 81, No 6 (2009)
- Pages: 27-28
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30345
- ID: 30345
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Abstract
Material and methods. We studied in vitro production of marker cytokines of type 1 T-helpers (IL-2), type 2 T-helpers (IL-4), type 3 T-helpers TGFb and type 1 T-regulators (IL-10) and counted CD4+CD25+ T-cells in the blood of patients with recurrent herpetic infection and having no clinical manifestations of Herpes virus reactivation.
Results. Patients with recurrent herpes had more active production of IL-10, but reduced count of CD4+CD25+ lymphocytes.
Conclusion. IL-10 hyperproduction observed in recurrent herpetic infection may contribute to progression of rheumatoid arthritis.
About the authors
V S Sviridova
E N Kologrivova
N A Pronina
L V Eliseeva
I O Naslednikova
V S Sviridova
E N Kologrivova
N A Pronina
L V Eliseeva
I O Naslednikova
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