Effects of recurrent herpetic infection on functional activity of T-cells in patients with rheumatoid arthritis


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Aim. To evaluate effects of recurrent herpetic infection on functional activity of regulatory cell subpopulations in patients with rheumatoid arthritis.
Material and methods. We studied in vitro production of marker cytokines of type 1 T-helpers (IL-2), type 2 T-helpers (IL-4), type 3 T-helpers TGFb and type 1 T-regulators (IL-10) and counted CD4+CD25+ T-cells in the blood of patients with recurrent herpetic infection and having no clinical manifestations of Herpes virus reactivation.
Results. Patients with recurrent herpes had more active production of IL-10, but reduced count of CD4+CD25+ lymphocytes.
Conclusion. IL-10 hyperproduction observed in recurrent herpetic infection may contribute to progression of rheumatoid arthritis.

参考

  1. Соловьева Н. Ю., Сенникова Ю. А., Гришина Л. В., Старостина Н. М. Провоспалительные и иммунорегуляторные цитокины у больных с синдромом вторичного иммунодефицита при рецидивирующей герпетической инфекции. Мед. иммунол. 2003; 5 (5-6): 583-590.
  2. Lan R. Y., Aftab Ansarib A., Zhe-Xiong L., Gershwina M. E. Regulatory T cells: development, function and role in autoimmunity. Autoimmun. Rev. 2005; 4 (6): 351-363.
  3. Marques C. P., Hu S., Sheng W. et al. Interleukin-10 attenuates production of HSV-induced inflammatory mediators by human microglia. Glia 2004; 47 (4): 358-366.
  4. Фрейдлин И. С. Паракринные и аутокринные механизмы цитокиновой иммунорегуляции. Аллергия, астма и клин. иммунол. 2000; 8: 73-80.
  5. Фрейдлин И. С. Регуляторные Т-клетки: происхождение и функции. Мед. иммунол. 2005; 7 (4): 347-354.
  6. Bach J. F. The effect of infection on susceptibility to autoimmune and allergic diseases. N Engl. J. Med. 2002; 347: 911-920.
  7. Cao D., Malmstrom V., Baecher-Allan C. et al. Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur. J. Immunol. 2003; 33 (1): 215-223.

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