Hair cell leukemia in young patients
- Authors: Al'-Radi LS1, Samoylova RS1, Tikhonova LY.1, Dyagileva OA1, Naumova IN1, Kaplanskaya IB1, Varlamova EY.1, Al-Radi LS1, Samoilova RS1, Tikhonova LY.1, Dyagileva OA1, Naumova IN1, Kaplanskaya IB1, Varlamova EY.1
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Affiliations:
- Issue: Vol 80, No 12 (2008)
- Pages: 53-58
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30256
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Abstract
Material and methods. The data on 41 HCL patients were analysed. The diagnosis was made by standard diagnostic protocol for HCL detection.
Results. The analysis of the age of 160 HCL patients studied demonstrated high (26%) incidence of HCL at young age. Young patients with HCL had special clinical manifestations and specific long-term outcomes of treatment with standard schemes.
Conclusion. Differences in occurrence of recurrences after standard therapy make it necessary to consider young HCL patients as a separate group who need adjuvant treatment to prolong remission.
Keywords
About the authors
L S Al'-Radi
R S Samoylova
L Yu Tikhonova
O A Dyagileva
I N Naumova
I B Kaplanskaya
E Yu Varlamova
L S Al-Radi
R S Samoilova
L Yu Tikhonova
O A Dyagileva
I N Naumova
I B Kaplanskaya
E Yu Varlamova
References
- Schrek R., Donnelly W. "Hairy" cells in blood in lymphoreticular neoplastic disease and "flagellated" cells of normal lymph nodes. Blood 1966; 27: 199-211.
- Bouroncle B., Wiseman B., Doan C. Leukemic reticuloendotheliosis. Blood 1958; 13: 609-630.
- Matutes E., Wotherspoon A., Catovsky D. The variant form of hairy-cell leukaemia. Best Pract. Res. Clin. Haematol. 2003; 16 (1): 41-56.
- Piro L., Carrera C., Carson D., Beutler E. Lasting remissions in hairy cell leukemia induced by a single dose of 2-chlorodeoxyadenosine. N. Engl. J. Med. 1990; 322: 1117-1121.
- Seven A., Burian C., Koziol J., Piro L. Long-term follow-up of patients with hairy cell leukemia after cladribine treatment. Blood 1998; 92: 1918-1926.
- Воробьев А. И. (ред.) Руководство по гематологии. 3-е изд. М.; 2005; т. 2: 90-91.
- Аль-Ради Л. С., Моисеева Т. Н., Меликян А. Л. и др. Современная терапия волосатоклеточного лейкоза. В кн.: I Всероссийский гематологический съезд: Тезисы. М.; 2002. 11.
- Hakimian D., Tallman M., Kiley C., Peterson L. Detection of minimal residual disease by immunostaining of bone marrow biopsies after 2-chlorodeoxyadenosine for hairy cell leukemia. Blood 1993; 82: 1802-1978.
- Fallman M., Hakimian D., Rademaker A. et al. Relapse of hairy cell leukemia after 2-chlorodeoxyadenosine long-term follow-up of the Northwestern University experience. Blood 1996; 88: 1954-1959.
- Fallman M., Hakimian D., Kopecky K. et al. Minimal residual disease in patients with hairy cell leukemia in complete remission treated with 2-chiorodeoxyadenosine or 2-deoxycoformycin and prediction of early relapse. Clin. Cancer Res. 1999; 5: 1665-1670.
