Hair cell leukemia in young patients


如何引用文章

全文:

详细

Aim. To characterize clinical symptoms, course, immediate and long-term treatment results in young patients with hair cell leukemia (HCL).
Material and methods. The data on 41 HCL patients were analysed. The diagnosis was made by standard diagnostic protocol for HCL detection.
Results. The analysis of the age of 160 HCL patients studied demonstrated high (26%) incidence of HCL at young age. Young patients with HCL had special clinical manifestations and specific long-term outcomes of treatment with standard schemes.
Conclusion. Differences in occurrence of recurrences after standard therapy make it necessary to consider young HCL patients as a separate group who need adjuvant treatment to prolong remission.

参考

  1. Schrek R., Donnelly W. "Hairy" cells in blood in lymphoreticular neoplastic disease and "flagellated" cells of normal lymph nodes. Blood 1966; 27: 199-211.
  2. Bouroncle B., Wiseman B., Doan C. Leukemic reticuloendotheliosis. Blood 1958; 13: 609-630.
  3. Matutes E., Wotherspoon A., Catovsky D. The variant form of hairy-cell leukaemia. Best Pract. Res. Clin. Haematol. 2003; 16 (1): 41-56.
  4. Piro L., Carrera C., Carson D., Beutler E. Lasting remissions in hairy cell leukemia induced by a single dose of 2-chlorodeoxyadenosine. N. Engl. J. Med. 1990; 322: 1117-1121.
  5. Seven A., Burian C., Koziol J., Piro L. Long-term follow-up of patients with hairy cell leukemia after cladribine treatment. Blood 1998; 92: 1918-1926.
  6. Воробьев А. И. (ред.) Руководство по гематологии. 3-е изд. М.; 2005; т. 2: 90-91.
  7. Аль-Ради Л. С., Моисеева Т. Н., Меликян А. Л. и др. Современная терапия волосатоклеточного лейкоза. В кн.: I Всероссийский гематологический съезд: Тезисы. М.; 2002. 11.
  8. Hakimian D., Tallman M., Kiley C., Peterson L. Detection of minimal residual disease by immunostaining of bone marrow biopsies after 2-chlorodeoxyadenosine for hairy cell leukemia. Blood 1993; 82: 1802-1978.
  9. Fallman M., Hakimian D., Rademaker A. et al. Relapse of hairy cell leukemia after 2-chlorodeoxyadenosine long-term follow-up of the Northwestern University experience. Blood 1996; 88: 1954-1959.
  10. Fallman M., Hakimian D., Kopecky K. et al. Minimal residual disease in patients with hairy cell leukemia in complete remission treated with 2-chiorodeoxyadenosine or 2-deoxycoformycin and prediction of early relapse. Clin. Cancer Res. 1999; 5: 1665-1670.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Consilium Medicum, 2008

Creative Commons License
此作品已接受知识共享署名-非商业性使用-相同方式共享 4.0国际许可协议的许可。
 

Address of the Editorial Office:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Correspondence address:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Managing Editor:

  • Tel.: +7 (926) 905-41-26
  • E-mail: e.gorbacheva@ter-arkhiv.ru

 

 © 2018-2021 "Consilium Medicum" Publishing house