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Prognostic implication of a focal lesion of bone marrow in diffuse large В cell lymphosarcoma
- Authors: Magomedova AU1, Kremenetskaya AM1, Vorobyev IA1, Kravchenko SK1, Kaplanskaya IВ1, Samoilova RS1, Gemdzhyan EG1, Vorobyev AI1
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- Issue: Vol 79, No 7 (2004)
- Pages: 60-63
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29997
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Abstract
Material and methods. 54 patients with histologically confirmed DBLCL were given first-line CHOP and CHOP-like courses from 1996 to 2003. B-cell nature of the tumor was confirmed immunohistochemically, immunophenotypically and with flow fluorimetry.
Results. In debute of the disease 16 patients had local involvement of the lymph organs (stage I-II by Enn-Arbor), 21 patients - generalized disease (stage III-IV) and 17 patients - involvement of nonlymphatic organs. Overall 3-year survival in first-line therapy in mature cell lesion of BM was 23%, without it - 0%. One-year event-free survival was 34 and 0%, respectively.
Conclusion. The presence of a focal mature cell lesion of BM in DBLCL patients influences the prognosis. Regarding high frequency of transformation of mature cell lymphoproliferative diseases in DBLCL . focal lesion of BM is an indirect sign of a secondary nature of the disease.
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About the authors
A U Magomedova
A M Kremenetskaya
I A Vorobyev
S K Kravchenko
I В Kaplanskaya
R S Samoilova
E G Gemdzhyan
A I Vorobyev
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