Email this article Antiphospholipid syndrome and exogenic factors ofthromboses risk
- Authors: Mach ES1, Shirokova IE1, Reshetnyak ТМ1, Tikhonova TМ1
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Affiliations:
- Issue: Vol 79, No 11 (2004)
- Pages: 71-74
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29960
- ID: 29960
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Abstract
Aim. To examine relationships between incidence rate of thromboses in antiphopholipid syndrome and
exogenic risk factors (RF) of thrombosis.
Material and methods. The trial enrolled 131 patients (105 females and 26 males). They were divided
into three groups: 23 patients with systemic lupus erythematosus (SLE, group 1), 63 patients with
SLE and antiphospholipid syndrome (APS, group 2), 45 patients with primary APS (PAPS, group 3).
Thrombosis RF questionnaire survey was made. Effects of corticosteroids and cyclophosphamide on
occurrence of thrombosis were assessed.
Results. Such exogenic RF as intake of coffee, fat food, alcohol were not related to thromboses. Hypodynamia
was more typical for APS patients (21.3%) than for SLE patients free of APS (8.7%). Overweight
for was characteristic for APS patients (49 and 34.7%, respectively). The proportion of smokers
was higher in APS patients, though smoking did not provoke thrombotic complications. A direct correlation
was found between occlusion and corticosteroids administration, while occlusion and cyclophosphamide
treatment correlated inversely.
Conclusion. Venous thrombosis RF in patients with APS and PAPS are obesity and treatment with
glucocorticosteroids
exogenic risk factors (RF) of thrombosis.
Material and methods. The trial enrolled 131 patients (105 females and 26 males). They were divided
into three groups: 23 patients with systemic lupus erythematosus (SLE, group 1), 63 patients with
SLE and antiphospholipid syndrome (APS, group 2), 45 patients with primary APS (PAPS, group 3).
Thrombosis RF questionnaire survey was made. Effects of corticosteroids and cyclophosphamide on
occurrence of thrombosis were assessed.
Results. Such exogenic RF as intake of coffee, fat food, alcohol were not related to thromboses. Hypodynamia
was more typical for APS patients (21.3%) than for SLE patients free of APS (8.7%). Overweight
for was characteristic for APS patients (49 and 34.7%, respectively). The proportion of smokers
was higher in APS patients, though smoking did not provoke thrombotic complications. A direct correlation
was found between occlusion and corticosteroids administration, while occlusion and cyclophosphamide
treatment correlated inversely.
Conclusion. Venous thrombosis RF in patients with APS and PAPS are obesity and treatment with
glucocorticosteroids
References
- Hansen К. Е., Kong D. F., Moore К. D., Ortel Т. L. Risk factors associated with thrombosis in patiens with antiphospholipid antibodies. J. Rheumatol. 2001; 28: 2018-2024.
- Голубев С. А., Милый М. Н. Кофе, чай и риск сердечно-сосудистых заболеваний. Кардиология 2001; 11: 99-103.
- Вак A. A. A., Grobbee D. Е. Caffeine, blood pressure, and serum lipids. Am. J. Clin. Nutr. 1991; 53: 971-975.
- Woodward M. Epidemiology of coagulation factors, inhibitors an activation markers: The third Glasgow Monica Survey Relationships to cardiovascular risk factors and prevalent cardiovascular disease. Br. J. Haematol. 1997; 97: 785-797.
- Шальнова С. А., Деев А. Д., Оганов Р. Г. Распространенность курения в России. Результаты обследования национальной представительной выборки населения. Профилактика заболеваний и укрепление здоровья 1998; 3: 9- 12.
- Lewis D. R., Van Dyke D. C, Stumbo P. J. et al. Drug and environmental factors associated with adverse pregnancy outcomes. Part 1: antiepileptic drugs, cumtraceptives, smoking and folate. Ann. Pharmacother. 1998; 32: 802-817.
- Оганов P. Г., Деев А. Д., Жуковский Г. С. и др. Влияние курения на смертность от хронических неинфекционных заболеваний по результатам проспективного исследования. Профилактика заболеваний и укрепление здоровья 1998; 3: 13-15.
- Tan Е. M., Cohen A. S., Fries J. F. et al. The 1982 revised criteria for classification of systemic lupus erythematosus. Arthr. and Rheum. 1982; 136: 347-354.
- Hughes G. R. V., Harris E. N., Charavi A. E. The anticardiolipin syndrome. J. Reumatol. 1986; 13: 486-489.
- Wilson W. A., Gharavi A. E., Koike T. et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome. Arthritis Rheum. 1999; 42: 1309-1311.
- Asherson R. A., Rhamashta M. A., Ordi-Ros J. et al. The "primary" antiphospholipid syndrome: major clinical and serological features. Medicine (Baltimore) 1989; 68: 366-374.
- Exner Т., Sahman N., Trudinger B. Separation of anticardiolipin antibodies from lupus anticoagulant on phospholipid-coated polysterine column. Biochem. Biophys. Res. Commun. 1988; 155: 1001-1007.
- Баркаган З. С., Момот А. П. Основы диагностики нарушения гемостаза. М: Ньюдиамед-АО; 1999. 215.
- Попова Л. В., Бокарев И. Н. Оценка значимости факторов риска венозного тромбоэмболизма. Тромбы, кровоточивость и болезни сосудов 2002; прил. 1: 101-103.
- Pawlowska Z. S., Swiatkowska М., Krzeslowska J. et al. Increased plateletfibrinogen interaction in patient with hypercholesterolemia and hypertriglyceridemia. Atherosclerosis 1993; 103: 13-20.
- Грацианский Н. А. Гормональная и заместительная терапия у женщин в период постменопаузы и сердечно-сосудистые заболевания. Труды VI Российского национального конгресса "Человек и лекарство"; 1999. 208-223.
- Насонов Е. Л. Противовоспалительная терапия ревматических болезней. М: М-Сити; 1996. 84-117.
- Попкова Т. В. Липид-белковый спектр крови при системной красной волчанке и антифосфолипидном синдроме. Дис... канд. мед. наук. М.; 1997.
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