New approaches to treatment of ischemic heart disease: therapeutic angiogenesis in combination with surgical revascularization of the myocardium
- Authors: Bockeria LA1, Golukhova EZ1, Eremeeva MV1, Kiselev SL1, Aslanidi IP1, Vakhromeeva MN1, Klyueva AF1, Polyakova ES1, Lukashkin MA1
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Affiliations:
- Issue: Vol 79, No 6 (2004)
- Pages: 25-30
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29816
- ID: 29816
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Abstract
Results. All the patients demonstrated a clinical response. The class of effort angina improved, the dose of the prescribed nitric drugs was decreased, exercise tolerance and total stress time rose, quality of life improved. Myocardial scintigraphy registered reduction of the total area and better accumulation of the radiopharmaceutical under load and at rest 3 and 6 months after the operation including myocardial areas which had not been revacularised at coronary artery bypass grafting but had been treated with the preparation of the human gene VEGF165.
Conclusion. The results of the study suggest that therapeutic angiogenesis may be an alternative impact on those myocardial areas which are suppled by the affected but ineligible for bypass grafting coronary arteries.
About the authors
L A Bockeria
E Z Golukhova
M V Eremeeva
S L Kiselev
I P Aslanidi
M N Vakhromeeva
A F Klyueva
E S Polyakova
M A Lukashkin
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