Predicting Futile Recanalization in Acute Ischemic Stroke Patients Undergoing Endovascular Thrombectomy: The Role of White Blood Cell Count to Mean Platelet Volume Ratio


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Abstract

Background:Approximately half of AIS patients have an unfavorable outcome even after complete reperfusion. White blood cell (WBC) count to mean platelet volume (MPV) ratio (WMR) may be a promising predictive factor for futile recanalization. This study aimed to determine the predictive value of WMR in identifying individuals at higher risk of futile recanalization.

Methods:In this retrospective cohort study, 296 patients who achieved complete reperfusion after endovascular treatment (EVT) were included in the analysis. WBC count and MPV were collected at admission. Multivariable logistic regression was used to examine the independent association of the WMR with functional outcomes at three months. Net reclassification improvement (NRI) and integrated discrimination improvement (IDI) analyses were used to compare the accuracy of WMR for predicting futile recanalization.

Results:The adjusted odds ratios for the fourth quartile of WMR were 3.142 (95% CI 1.405- 7.027, P = 0.005) for unfavorable outcomes at 3 months in comparison with the first quartile. The inclusion of WMR in the traditional model enabled a more accurate prediction of unfavorable outcomes (NRI 0.250, P = 0.031; IDI 0.022, P = 0.017).

Conclusion:Elevated WMR at admission was independently associated with futile recanalization among AIS patients who received EVT and might be useful in identifying futile recanalization.

About the authors

Wantong Yu

Department of Neurology, Xuanwu Hospital, Capital Medical University

Email: info@benthamscience.net

Milan Jia

Department of Neurology, Xuanwu Hospital, Capital Medical University

Email: info@benthamscience.net

Wenting Guo

Department of Neurology, Xuanwu Hospital, Capital Medical University

Email: info@benthamscience.net

Jiali Xu

Department of Neurology, Xuanwu Hospital, Capital Medical University

Email: info@benthamscience.net

Changhong Ren

Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital, Capital Medical University

Email: info@benthamscience.net

Sijie li

Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital, Capital Medical University

Email: info@benthamscience.net

Wenbo Zhao

Department of Neurology, Xuanwu Hospital, Capital Medical University

Email: info@benthamscience.net

Jian Chen

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University

Email: info@benthamscience.net

Jiangang Duan

Department of Emergency, Xuanwu Hospital, Capital Medical University

Email: info@benthamscience.net

Qingfeng Ma

Department of Neurology, Xuanwu Hospital, Capital Medical University

Email: info@benthamscience.net

Haiqing Song

Department of Neurology, Xuanwu Hospital, Capital Medical University

Email: info@benthamscience.net

Xunming Ji

Department of Neurology, Xuanwu Hospital, Capital Medical University Beijing

Author for correspondence.
Email: info@benthamscience.net

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