Long-Term Memory: The Role of Light and Learning in Coping with Stress in Drosophila Melanogaster

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The formation of a conditional connection allows the organism to change its reactions to various environmental factors, combining and mobilizing the necessary internal adaptive processes. It is assumed that there are common mechanisms underlying the formation of adaptive processes – stress response and learning. To develop methods for non-invasive correction of nervous system pathologies at a model object of genetics – Drosophila, the relationship of adaptive mechanisms of the formation of a conditional connection and the development of a stressor reaction to the weakening of the Earth’s magnetic field in light: dark conditions was studied. The role of learning and lighting in overcoming stress in connection with the formation of long-term memory in the paradigm of conditioned courtship suppression was revealed. Within the framework of quantum dynamics of electronic and nuclear spins of transition states of radical molecules, the hypothesis of their participation in the formation of long-term memory is considered.

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作者简介

E. Tokmacheva

Pavlov Institute of Physiology of the Russian Academy of Sciences

Email: 21074@mail.ru
俄罗斯联邦, Saint Petersburg

A. Medvedeva

Pavlov Institute of Physiology of the Russian Academy of Sciences

Email: 21074@mail.ru
俄罗斯联邦, Saint Petersburg

B. Shchegolev

Pavlov Institute of Physiology of the Russian Academy of Sciences

Email: 21074@mail.ru
俄罗斯联邦, Saint Petersburg

E. Nikitina

Pavlov Institute of Physiology of the Russian Academy of Sciences; Herzen Russian State Pedagogical University

编辑信件的主要联系方式.
Email: 21074@mail.ru
俄罗斯联邦, Saint Petersburg; Saint Petersburg

E. Savvateeva-Popova

Pavlov Institute of Physiology of the Russian Academy of Sciences

Email: 21074@mail.ru
俄罗斯联邦, Saint Petersburg

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2. Fig. 1. Dynamics of preservation of conditioned reflex suppression of courtship during testing of long-term memory in the wild-type line Canton S. a - intact control, b - exposure to the Earth's OSMP (12 hours of exposure). On the abscissa axis: time after training completion, days; on the ordinate axis: EI - learning index, %. * - IE is significantly different from the intact control; # - IE in the delayed test is significantly lower than in the test immediately after training (two-sided randomisation test, αR < 0.05)

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3. Fig. 2. Dynamics of preservation of conditioned reflex suppression of courtship in the wild-type line Canton S during training in the Earth's OSMP. a - training in the dark, b - training in the light. On the abscissa axis: time after training completion, days; on the ordinate axis: CI - learning index, %. * - CI is significantly different from intact control; # - CI in the delayed test is significantly lower than in the test immediately after training (two-sided randomisation test, αR < 0.05)

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4. Fig. 3. Dynamics of preservation of conditioned reflex suppression of courtship in the wild-type line Canton S under exposure to the Earth's OSMP (5 hours of exposure to light). On the abscissa axis: time after training completion, days; on the ordinate axis: CI - learning index, %. * - IE is significantly different from the intact control; # - IE in the delayed test is significantly lower than in the test immediately after training (two-sided randomisation test, αR < 0.05)

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