Analysis of the gene polymorphism of matrix metalloproteinase-2 and -9 in patients with coronary heart disease


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Aim. To analyze the gene polymorphisms of matrix metalloproteinase-2 and -9 in patients with coronary heart disease (CHD).
Materials and methods. The influence of single nucleotide polymorphism in the promoter region of the gene of matrix metalloproteinase (MMP)-2 at position -1306 and that of MMP-9 at position -1562 on the development of complications was studied in 181 patients with atherosclerosis by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis of amplification products.
Results. A significant genotype increase with enhanced MMP-9 gene transcriptional activity was found in the patients aged 55 years inclusively who had been diagnosed as having myocardial infarction as compared with an older age group and, on the contrary, a rise in the MMP-2 genotype with a high promoter activity in the older age group.
Conclusion. The findings suggest that the functional polymorphism in the promoter region of the MMP-2 and MMP-9 genes plays a certain role in the development of acute coronary events.

作者简介

Alla Shevchenko

Email: shalla64@mail.ru

Ol'ga Golovanova

Email: golovanova_olga@mail.ru

Vladimir Konenkov

Email: konen@soramn.ru

Ol'ga Tolkacheva

Email: tolkacheva-olga@mail.ru

Vladimir Maksimov

Email: medik11@mail.ru

Mikhail Voevoda

Email: voevoda@iimed.ru

Aida Romashchenko

Email: romasch@bionet.nsc.ru

A Shevchenko

Clinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical Sciences

Clinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical Sciences

O Golovanova

Clinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical Sciences

Clinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical Sciences

V Konenkov

Clinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical Sciences

Clinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical Sciences

O Tolkacheva

Town Clinical Hospital Twenty-Nine

Town Clinical Hospital Twenty-Nine

V Maksimov

Research Institute of Therapy, Siberian Branch, Russian Academy of Medical Sciences

Research Institute of Therapy, Siberian Branch, Russian Academy of Medical Sciences

M Voyevoda

Research Institute of Therapy, Siberian Branch, Russian Academy of Medical Sciences

Research Institute of Therapy, Siberian Branch, Russian Academy of Medical Sciences

A Romashchenko

Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences

Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences

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