Chronic obstructive pulmonary disease concurrent with hypertension: Evaluation of the therapeutic effect of prolonged-release indapamide
- 作者: Ovcharenko SI1, Morozova TE1, Nersesyan ZN1
-
隶属关系:
- 期: 卷 87, 编号 8 (2015)
- 页面: 44-50
- 栏目: Editorial
- ##submission.dateSubmitted##: 10.04.2020
- ##submission.datePublished##: 15.08.2015
- URL: https://ter-arkhiv.ru/0040-3660/article/view/31795
- ID: 31795
如何引用文章
全文:
详细
Aim. To provide a rationale for the clinical efficacy and safety of prolonged-release indapamide used in the combination therapy of patients with chronic obstructive pulmonary disease concurrent (COPD) concurrent with hypertension. Subjects and methods. Sixty-five patients (50 men and 15 women) with Stages I—IV COPD and grades 1—3 elevated blood pressure (BP) in whom prior antihypertensive therapy had proved insufficiently effective were examined. Results. Prolonged-release indapamide demonstrated a high efficacy in achieving and maintaining goal BP, in normalizing its daily profile, and in reducing increased variability and the rate of morning rise in BP, without negatively affecting the clinical manifestations of COPD, pulmonary ventilatory function, and serum potassium levels. The drug was shown to have additional pleiotropic effects in lowering the activity of inflammatory markers (high-sensitivity C-reactive protein, intercellular adhesion molecules-1) and the level of endothelial dysfunction markers (endothelin-1, sP-selectin). Another commonly clinically used diuretic hydrochlorothiazide was chosen as a compared drug. Conclusion. The high antihypertensive efficacy and additional pleiotropic properties of prolonged-release indapamide that exerts no negative effect on the clinical manifestations of COPD, bronchial patency, and serum potassium levels demonstrate that it is expedient to incorporate prolonged-release indapamide into the combination therapy of patients with COPD concurrent with hypertension.
参考
- Anthonisen NR, Connett JE, Enright PL, Manfreda J. Lung Health Study Research Group. Hospitalizations and mortality in the Lung Health Study. Am J RespirCrit Care Med. 2002;166:333-339. doi: 10.1164/rccm.2110093.
- Задионченко В.С., Адашева Т.В., Федорова И.В., Нестеренко О.И., Миронова М.А. Артериальная гипертония и хроническая обструктивная болезнь легких — клинико-патогенетические параллели и возможности терапии. Российский кардиологический журнал. 2009;6:62-69.
- Палеев Н.Р., Распопина Н.А., Федорова С.И., Шуганов Е.Г., Агальцов М.В. Существует ли «пульмогенная гипертензия»? Кардиология. 2002;6:51-53.
- Кароли Н.А., Ребров А.П. Коморбидность у больных хронической обструктивной болезнью легких: место кардиоваскулярной патологии. Рациональная фармакотерапия в кардиологии. 2009;4:9-16.
- Suylen RI, Smits JF, Daemen MJ. Pulmonary artery remodeling difference in hypoxia and monocrotaline induced pulmonary hypertension. Am J Respir Сrit Care Med. 1998;157(8):1423-1428. doi: 10.1164/ajrccm.157.5.9709050.
- Heitzer T, Schlinzig T, Krohn K, Meinertz T, Munzel T. Endothelial dysfunction, oxidative stress and risk of cardiovascular events in patients with coronary disease. Circulation. 2001;104:2673-2678. doi: 10.1161/hc4601.099485.
- Lucher T.F., Noll G. The pathogenesis of cardiovascular disease: role of the endothelium as a target and mediator. Atherosclerosis. 1995;118:81-90. doi: 10.1016/0021-9150(95)90075-6.
- Задионченко В.С., Адашева Т.В., Шилова Е.В., Погонченкова И.В., Заседателева Л.В., Ли В.В. Клинико-функциональные особенности артериальной гипертонии у больных хронической обструктивной болезнью легких. Русский медицинский журнал. 2003;9:535-539.
- Адашева Т.В., Задионченко В.С., Мациевич М.В., Ли В.В., Шилова А.В., Федорова И.В. Артериальная гипертония и ХОБЛ — рациональный выбор терапии. Русский медицинский журнал. 2006;10(262):795-800.
- Gosse P, Sheridan DJ, Zannad F, Dubourg O, Guéret P, Karpov Y, de Leeuw PW, Palma-Gamiz JL, Pessina A, Motz W, Degaute JP, Chastang C. Regression of left ventricular hypertrophy in hypertensive patients treated with indapamide SR 1,5 mg versus enalapril 20 mg: the LIVE study. J Hypertens. 2000;18:1465-1475. doi: 10.1097/00004872-200018100-00015.
- Marre M, Puig JG, Kokot F, Fernandez M, Jermendy G, Opie L, Moyseev V, Scheen A, Ionescu-Tirgoviste C, Saldanha MH, Halabe A, Williams B, Mion Júnior D, Ruiz M, Hermansen K, Tuomilehto J, Finizola B, Gallois Y, Amouyel P, Ollivier JP, Asmar R. Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type2 diabetes: the NESTOR study. J Hypertens. 2004;22:1613-1622. doi: 10.1097/01.hjh.0000133733.32125.09.
- Warwick J, Falaschetti E, Rockwood K, Mitnitski A, Thijs L, Beckett N, Bulpitt C, Peters R. No evidence that frailty modifies the positive impact of antihypertensive treatment in very elderly people: an investigation of the impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 and over. BMC Med. 2015;13:78. doi: 10.1186/s12916-015-0328-1.
- Junquero DC, Schini VB, Vanhoutte PM. Indapamide potentiates the endothelium-depend production of cyclic guanosine monophosphate by bradykinine in the canine femoral artery. Am Heart J. 1991;122(2):1204-1209. doi: 10.1016/0002-8703(91)90940-j.
- Ambrosioni E, Safar M, Degaute JP, Malin PL, MacMahon M, Pujol DR, de Cordoüe A, Guez D. Low-dose antihypertensive therapy with 1,5 mg sustained-release indapamide: results of randomized double-blind controlled studies. European Study Group. J Hypertens. 1998;16:1677-1684.
- Schini VB, Dewey J, Vanhoutte PM. Indapamide potentiates the endothelium-depend relaxation in isolated canine femoral arteries. Am J Cardiol. 1990;65(17):6-10. doi: 10.1016/0002-9149(90)90336-y.
- Psaty BM, Smith NL, Siscovick DS, Koepsell TD, Weiss NS, Heckbert SR, Lemaitre RN, Wagner EH, Furberg CD. .Health outcomes associated with antihypertensive therapies used as first-line agents. А systematic review and meta-analysis. JAMA. 1997;277:739-745. doi: 10.1001/jama.277.9.739.
补充文件
![](/img/style/loading.gif)