Positive effect of low-activity thromboxane A synthase 1 gene on prognosis in coronary heart disease


如何引用文章

全文:

详细

Aim. To analyze the influence of pharmacogenetic factors on the risk of clopidogrel resistance and cardiovascular events during 18-months follow-up. Subjects and methods. Two hundred and fifty patients taking clopidogrel were examined. Platelet function was determined by optical aggregometry. Thromboxane A synthase 1 (TBS1) gene polymorphism was investigated in all the patients. The impact of TBS1 gene polymorphism on the risk of clopidogrel resistance and cardiovascular events was analyzed during 18 months of follow-up. Results. The carriage of TBS1 gene polymorphism AA was shown to affect the risk of clopidogrel resistance. Cardiovascular complications significantly less frequently occurred in TBS1 gene polymorphism AA carriers during 18 months. Conclusion. The carriage of a slow AA allele of the TBS1 gene is suggested to be a clinically significant protective factor in the secondary prevention of coronary heart disease

参考

  1. Айнетдинова Д.Х. Резистентность к антитромбоцитарным препаратам у больных с острыми коронарными синдромами: Дис. ... канд. мед. наук. М 2008: 22—36.
  2. Sun Ah, Byung Lae, Jeong Ho. Association of polymorphisms in thromboxane A2 receptor and thromboxane A synthase 1 with cerebral infarction in a Korean population. BMB 2009; 42 (4): 200—205.
  3. Yu Fang, Yi Xue, Za Zhi. Association of Rs10487667 genetic polymorphism of thromboxane synthase with myocardial infarction in Uigur population of Xinjiang. Heart 2010; 44 (11): 1032—1036.
  4. Oh S.H., Kim Y.H., Park S.M. et al. Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients. Pharmacogenomics 2011; 12 (3): 351—363.
  5. Bhavaraju K., Georgakis A., Jin J. Antagonism of P2Y12 reduces physiological thromboxane levels. Platelets 2010; 21 (8): 604—609.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Consilium Medicum, 2015

Creative Commons License
此作品已接受知识共享署名-非商业性使用-相同方式共享 4.0国际许可协议的许可。
 

Address of the Editorial Office:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Correspondence address:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Managing Editor:

  • Tel.: +7 (926) 905-41-26
  • E-mail: e.gorbacheva@ter-arkhiv.ru

 

 © 2018-2021 "Consilium Medicum" Publishing house


##common.cookie##