Significance of allelic variants of interleukin-28B gene in chronic hepatitis C
- 作者: Tikhonova NI.1, Burnevich ÉZ1, Krasnova TN1
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隶属关系:
- 期: 卷 85, 编号 12 (2013)
- 页面: 106-113
- 栏目: Editorial
- ##submission.dateSubmitted##: 10.04.2020
- ##submission.datePublished##: 15.12.2013
- URL: https://ter-arkhiv.ru/0040-3660/article/view/31408
- ID: 31408
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Chronic hepatitis C remains one of the most urgent problems of today's medicine. The review unravels the current view of the role of a single nucleotide polymorphism of the interleukin-28B (IL-28B) gene in different aspects of hepatitis C virus infection. Major attention is paid to the discussion of the value of the allelic variants of IL-28B during standard double and current triple antiviral therapy for chronic hepatitis C. Furthermore, the paper covers the biological role of interferon-λ, a product of IL-28A, B, and IL-29 gene expression, other associations of the allelic variants of the IL-28B gene with different clinical signs, as well as the possibilities of practical use of this genetic marker in chronic hepatitis C today and futures prospects.
全文:
Значение аллельных вариантов гена интерлейкина-28В при хроническом гепатите С. - Аннотация. Хронический гепатит С остается одной из наиболее актуальных проблем сегодняшней медицины. В обзоре раскрывается современный взгляд на роль полиморфизма единичных нуклеотидов гена интерлейкина-28В (ИЛ-28В) при различных аспектах инфекции вирусом гепатита С. Основное внимание уделено обсуждению значения аллельных вариантов ИЛ-28В при проведении стандартной двухкомпонентной и современной трехкомпонентной противовирусной терапии хронического гепатита С. Кроме того, освещаются биологическая роль интерферона-λ - продукта экспрессии генов ИЛ-28А, В и ИЛ-29, другие ассоциации аллельных вариантов гена ИЛ-28В с различными клиническими признаками, возможности практического применения данного генетического маркера при хроническом гепатите С в настоящее время и перспективы на будущее.×
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