Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya31408Editorial articleПередовая статьяReview ArticleSignificance of allelic variants of interleukin-28B gene in chronic hepatitis CЗначение аллельных вариантов гена интерлейкина-28В при хроническом гепатите СTikhonovaN IuТихоноваН Юtikhonova.msu@gmail.comBurnevichÉ ZБурневичЭ ЗKrasnovaT NКрасноваТ НМГУ им. М.В. ЛомоносоваПервый МГМУ им. И.М. Сеченова Минздрава России151220138512VOL 85, NO12 (2013)ТОМ 85, №12 (2013)10611310042020Copyright ©; 2013, Consilium MedicumCopyright ©; 2013, ООО "Консилиум Медикум"2013Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/31408

Chronic hepatitis C remains one of the most urgent problems of today's medicine. The review unravels the current view of the role of a single nucleotide polymorphism of the interleukin-28B (IL-28B) gene in different aspects of hepatitis C virus infection. Major attention is paid to the discussion of the value of the allelic variants of IL-28B during standard double and current triple antiviral therapy for chronic hepatitis C. Furthermore, the paper covers the biological role of interferon-λ, a product of IL-28A, B, and IL-29 gene expression, other associations of the allelic variants of the IL-28B gene with different clinical signs, as well as the possibilities of practical use of this genetic marker in chronic hepatitis C today and futures prospects.

Аннотация. Хронический гепатит С остается одной из наиболее актуальных проблем сегодняшней медицины. В обзоре раскрывается современный взгляд на роль полиморфизма единичных нуклеотидов гена интерлейкина-28В (ИЛ-28В) при различных аспектах инфекции вирусом гепатита С. Основное внимание уделено обсуждению значения аллельных вариантов ИЛ-28В при проведении стандартной двухкомпонентной и современной трехкомпонентной противовирусной терапии хронического гепатита С. Кроме того, освещаются биологическая роль интерферона-λ - продукта экспрессии генов ИЛ-28А, В и ИЛ-29, другие ассоциации аллельных вариантов гена ИЛ-28В с различными клиническими признаками, возможности практического применения данного генетического маркера при хроническом гепатите С в настоящее время и перспективы на будущее.

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