电邮这篇文章 Implication of functional platelet activity in pathogenesis of Q-fever
- 作者: Lazareva E.N.1, Maleev V.V.1, Galimzyanov K.M1, Burkin A.V.1, Polyakova A.M.1, Astrina O.S.1, Babaeva MA1, Khok MM1, Lazareva EN2,3, Maleev VV4, Galimzyanov K.M3, Burkin AV2, Khok MM2, Polyakova AM4, Astrina OS4, Babaeva MA2
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隶属关系:
- Regional Infectious Hospital, Astrakhan
- State Medical Academy, Astrakhan
- Central Research Institute of Epidemiology, Astrakhan
- 期: 卷 83, 编号 11 (2011)
- 页面: 51-55
- 栏目: Editorial
- ##submission.dateSubmitted##: 10.04.2020
- ##submission.datePublished##: 15.11.2011
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30949
- ID: 30949
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Material and methods. We studied hemostasis with estimation of functional platelet activity in 49 patients with Q-fever.
Results. Hemorrhagic syndrome (HS) occurred in 34,4 % patients with Q-fever (QF) during seasonal rise of morbidity. HS manifested with petechiae (12%), hematomas (32 %), nasal bleeding (17 %), stomatorrhagia (9 %), melena (12 %). Characteristics and duration of such symptoms as weakness (100%), myalgia (72%), arthralgia (52.9%) suggested hemocoagulatory disorders as a cause of the symptoms appearance. At the height of the disease thrombocytopenia was accompanied with inhibition of platelet aggregation activity, but regression of the clinical symptoms was associated with an increase in platelet count and platelet hyperaggregation. Fibrinogen content was elevated during hospitalization in 50% patients.
Conclusion. Clinical manifestations of HS are typical for Q-fever prevalent in the Astrakhan Region. Hemostatic disorders because of altered functional activity of platelets were registered in all the cases and evidence for pathogenetic unbalance of homeostasis in Q-fever patients.
作者简介
Elena Lazareva
Email: elniklazareva@yandex.ru
Viktor Maleev
Khalip Galimzyanov
Aleksandr Burkin
Alla Polyakova
Ol'ga Astrina
M Babaeva
M Khok
E Lazareva
Regional Infectious Hospital, Astrakhan;State Medical Academy, AstrakhanRegional Infectious Hospital, Astrakhan;State Medical Academy, Astrakhan
V Maleev
Central Research Institute of Epidemiology, AstrakhanCentral Research Institute of Epidemiology, Astrakhan
Kh Galimzyanov
State Medical Academy, AstrakhanState Medical Academy, Astrakhan
A Burkin
Regional Infectious Hospital, AstrakhanRegional Infectious Hospital, Astrakhan
M Khok
Regional Infectious Hospital, AstrakhanRegional Infectious Hospital, Astrakhan
A Polyakova
Central Research Institute of Epidemiology, AstrakhanCentral Research Institute of Epidemiology, Astrakhan
O Astrina
Central Research Institute of Epidemiology, AstrakhanCentral Research Institute of Epidemiology, Astrakhan
M Babaeva
Regional Infectious Hospital, AstrakhanRegional Infectious Hospital, Astrakhan
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