Current methods of diagnosis and monitoring of a systemic amyloidosis course
- 作者: Rameev V.V.1, Kozlovskaya L.V.1, Malinina E.A.1, Serova A.G.1, Kogarko I.N.1, Kogarko B.S.1, Lyubimova N.V.1, Rameev VV2, Kozlovskaya LV2, Malinina EA2, Serova AG2, Kogarko IN3, Kogarko BS3, Lyubimova NV4
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隶属关系:
- I.M. Sechenov First Moscow State Medical University
- N.N. Semenov Institute of Chemical Physics, Moscow
- N.N. Blokhin Russian Cancer Research Center, Moscow
- 期: 卷 83, 编号 8 (2011)
- 页面: 48-54
- 栏目: Editorial
- ##submission.dateSubmitted##: 10.04.2020
- ##submission.datePublished##: 15.08.2011
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30902
- ID: 30902
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Material and methods. SAA concentrations were studied with ELISA in 43 rheumatoid arthritis (RA) patients including complicated with reactive AA-amyloidosis (n = 31). Inflammation activity and its severity were studied (indices Li, richi, HAQ, DAS4). A modern quantitative nephelometric method Freelite estimated ILC levels in 31 patients with AL-amyloidosis.
Results. Patients with RA complicated with AA-amyloidosis and free of it had a strong correlation between blood serum SAA concentration and activity of joint disease. Elevated SAA concentrations to 160 mg/l (normal 10 mg/l) were detected in many patients with clinical remission of the joint syndrome. Significal inhibition of AA-amyloidosis progression was seen only in SAA concentration drop under 60 mg/l. For AL-amyloidosis patients ILC fall by less than 3 normal value means a 6-time increase in chances of a favourable outcome.
Conclusion. Monitoring of blood levels of proteins precursors of AA- and AL-amyloidosis is a key factor in prognosis of the disease and treatment efficacy.
作者简介
Vilen Rameev
Email: vvrameev@mtu-net.ru
Lidiya Kozlovskaya
Elena Malinina
Email: knvpb@mma.ru
Anna Serova
Ivetta Kogarko
Bronislav Kogarko
Nina Lyubimova
V Rameev
I.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical University
L Kozlovskaya
I.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical University
E Malinina
I.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical University
A Serova
I.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical University
I Kogarko
N.N. Semenov Institute of Chemical Physics, MoscowN.N. Semenov Institute of Chemical Physics, Moscow
B Kogarko
N.N. Semenov Institute of Chemical Physics, MoscowN.N. Semenov Institute of Chemical Physics, Moscow
N Lyubimova
N.N. Blokhin Russian Cancer Research Center, MoscowN.N. Blokhin Russian Cancer Research Center, Moscow
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