Acardioprotective drug nikorandil in coronary heart disease


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Abstract

Nicorandil, opener of potassium channels, was studied in Russia and abroad. Its cardioprotective, anti-ischemic, pharmacokinetic and pharmacodynamic properties are reviewed as well as side effects and area of application in patients with stable coronary heart disease (CHD). The trial have found efficacy of nicorandil in prevention of anginal attacks. Also, the drug increases exercise tolerance. Administration of nicorandil is indicated before intervention on coronary arteries for reproduction of the effect of myocardial preconditioning. Nicorandil is recommended for treatment of patients with chronic stable coronary heart disease.

About the authors

Anna Mikhaylovna Malysheva

Email: amalysheva@ Gnicpm.ru

Sergey Yur'evich Martsevich

Moisey L'vovich Ginzburg

A M Malysheva

Prophylactic Medicine Research Center, Moscow

Prophylactic Medicine Research Center, Moscow

S Yu Martsevich

Prophylactic Medicine Research Center, Moscow; State I.M. Sechenov First Medical University

Prophylactic Medicine Research Center, Moscow; State I.M. Sechenov First Medical University

M L Ginzburg

District hospital N 2, Lyubertsy

District hospital N 2, Lyubertsy

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