An IL-6 level in the serum and urine in estimation of cryoglobulinemic vasculitis activity in patients with chronic hepatitis C associated with renal damage


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Aim. To estimate serum and urine IL-6 levels and to study its role in diagnosis of nephritis activity in patients with cryoglobulinemic glomerulonephritis (CGN) associated with chronic hepatitis C (CHC).
Material and methods. Enzyme immunoassay was used to assay IL-6 in blood serum of 124 patients having different stages of CHC. IL-6 was also estimated in the urine of 57 patients with CHC systemic manifestations including renal damage.
Results. Abnormal serum IL-6 level was seen in 36% CHC patients. Patients with elevated level of IL-6 in the serum vs patients with normal IL-6 level had cryoglobulinemia (CGE) (56% vs 26%, p < 0.01) and related systemic manifestations including cryoglobulinemic glomerulonephritis (30% vs 9%, p < 0.01). Most of (90%) patients with CHC-associated CGN had urinary IL-6 excretion correlating with severity of renal damage: the highest urinary level of IL-6 was seen in development of acute nephritic and nephritic syndromes (from 83.5 to 250 pg/ml). It did not correlate with IL-6 in the serum and proteinuria. This is evidence that IL-6 in the urine had a local origin (intrarenal), reflecting activity of immune inflammation in the kidney.
Conclusion. Control of IL-6 levels in the blood serum and urine of patients suffering from CHC with cryoglobulinemic syndrome and renal damage can be used for monitoring of the disease activity.

作者简介

Yuliya Korotchaeva

Email: lumis-j@bk.ru

Lidiya Kozlovskaya

Nadezhda Gordovskaya

Anatoliy Speranskiy

Yu Korotchaeva

I.M. Sechenov State Medical University, Moscow

I.M. Sechenov State Medical University, Moscow

L Kozlovskaya

Nephrology and Occupational Diseases Clinic, Moscow

Nephrology and Occupational Diseases Clinic, Moscow

N Gordovskaya

I.M. Sechenov State Medical University, Moscow

I.M. Sechenov State Medical University, Moscow

A Speransky

Institute of Rheumatology, Moscow

Institute of Rheumatology, Moscow

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