Outcomes of severe pandemic influenza A/H1N1/2009
- 作者: Klimova E.A.1, Yushchuk N.D.1, Karetkina G.N.1, Boytsov P.V.1, Serobyan A.G.1, Kelli E.I.1, Malyshev N.A.1, Golokhvastova N.O.1, Esaulova M.R.1, Karchevskaya N.A.1, Avdeev S.N.1, Klimova EA2, Yushchuk ND2, Karetkina GN2, Boitsov PV3, Serobyan AG3, Kelli EI3, Malyshev NA3, Golokhvastova NO2, Esaulova MR3, Karchevskaya NA4, Avdeyev SN4
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隶属关系:
- Moscow State University of Medicine and Dentistry
- Infectious Clinical Hospital One
- Research Institute of Pulmonology, Federal Biomedical Agency
- 期: 卷 82, 编号 11 (2010)
- 页面: 15-18
- 栏目: Editorial
- ##submission.dateSubmitted##: 09.04.2020
- ##submission.datePublished##: 15.11.2010
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30696
- ID: 30696
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Subjects and methods. The study enrolled 24 patients, including 8 males and 16 females (10 of whom were pregnant), aged 17 to 58 years, with a laboratorily verified diagnosis of pandemic influenza A/H1N1/2009, treated at the intensive care unit for the significant symptoms of acute respiratory failure (RF). Real-time RT-PCR was used to verify the diagnosis. Organs and tissues from deceased patients were histologically studied; chest computed tomography, body plethysmography, fibrobronchoscopy, breath test, and 6-minute walk test were performed in the late period.
Results. Within the first 30 days, a fatal outcome caused by therapy-resistant progressive RF was observed in 33% of the patients with pandemic influenza treated at the intensive care unit. Diffuse alveolar damage caused by influenza virus, which gives rise to hyaline membranes, underlies RF. Lung tissue fibrosis formed in recovered patients.
Conclusion. The severity of pandemic influenza A/H1N1/2009 was determined by massive bilateral pneumonia, interstitial (alveolar) pulmonary edema, formation of diffuse bilateral lung fibrosis at the outcome of severe virus pneumonia (acute respiratory distress syndrome) with a decrease in vital and diffusing capacities, thereby generating a need to follow up this patient category and, possibly, to elaborate special rehabilitation programs.
作者简介
Elena Klimova
Email: elena_klimova@mail.ru
Nikolay Yushchuk
Email: msmsu_rector@mtu-net.ru
Galina Karetkina
Email: karetkinagn@mail.ru
Pavel Boytsov
Email: ikb1@mosgorzdrav.ru
Avet Serobyan
Email: ikb1@mosgorzdrav.ru
Elena Kelli
Email: ekelly@yandex.ru
Nikolay Malyshev
Email: ikb1@mosgorzdrav.ru
Natal'ya Golokhvastova
Email: pavo@mail.ru
Madina Esaulova
Email: emadina@inbox.ru
Natal'ya Karchevskaya
Email: karchevskaia@mail.ru
Sergey Avdeev
Email: serg_avdeev@list.ru
E Klimova
Moscow State University of Medicine and DentistryMoscow State University of Medicine and Dentistry
N Yushchuk
Moscow State University of Medicine and DentistryMoscow State University of Medicine and Dentistry
G Karetkina
Moscow State University of Medicine and DentistryMoscow State University of Medicine and Dentistry
P Boitsov
Infectious Clinical Hospital OneInfectious Clinical Hospital One
A Serobyan
Infectious Clinical Hospital OneInfectious Clinical Hospital One
E Kelli
Infectious Clinical Hospital OneInfectious Clinical Hospital One
N Malyshev
Infectious Clinical Hospital OneInfectious Clinical Hospital One
N Golokhvastova
Moscow State University of Medicine and DentistryMoscow State University of Medicine and Dentistry
M Esaulova
Infectious Clinical Hospital OneInfectious Clinical Hospital One
N Karchevskaya
Research Institute of Pulmonology, Federal Biomedical AgencyResearch Institute of Pulmonology, Federal Biomedical Agency
S Avdeyev
Research Institute of Pulmonology, Federal Biomedical AgencyResearch Institute of Pulmonology, Federal Biomedical Agency
参考
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