Outcomes of severe pandemic influenza A/H1N1/2009

Elena Anatol'evna Klimova; Климова Елена Анатольевна; Nikolay Dmitrievich Yushchuk; Ющук Николай Дмитриевич; Galina Nikolaevna Karetkina; Кареткина Галина Николаевна; Pavel Vladimirovich Boytsov; Бойцов Павел Владимирович; Avet Grigor'evich Serobyan; Серобян Авет Григорьевич; Elena Ivanovna Kelli; Келли Елена Ивановна; Nikolay Aleksandrovich Malyshev; Малышев Николай Александрович; Natal'ya Olegovna Golokhvastova; Голохвастова Наталья Олеговна; Madina Ruslanovna Esaulova; Есаулова Мадина Руслановна; Natal'ya Anatol'evna Karchevskaya; Карчевская Наталья Анатольевна; Sergey Nikolaevich Avdeev; Авдеев Сергей Николаевич; E A Klimova; Klimova E A; N D Yushchuk; Yushchuk N D; G N Karetkina; Karetkina G N; P V Boitsov; Boitsov P V; A G Serobyan; Serobyan A G; E I Kelli; Kelli E I; N A Malyshev; Malyshev N A; N O Golokhvastova; Golokhvastova N O; M R Esaulova; Esaulova M R; N A Karchevskaya; Karchevskaya N A; S N Avdeyev; Avdeyev S N

Outcomes of severe pandemic influenza A/H1N1/2009

作者: Klimova E.A.¹, Yushchuk N.D.¹, Karetkina G.N.¹, Boytsov P.V.¹, Serobyan A.G.¹, Kelli E.I.¹, Malyshev N.A.¹, Golokhvastova N.O.¹, Esaulova M.R.¹, Karchevskaya N.A.¹, Avdeev S.N.¹, Klimova EA², Yushchuk ND², Karetkina GN², Boitsov PV³, Serobyan AG³, Kelli EI³, Malyshev NA³, Golokhvastova NO², Esaulova MR³, Karchevskaya NA⁴, Avdeyev SN⁴
隶属关系:
2. Moscow State University of Medicine and Dentistry
3. Infectious Clinical Hospital One
4. Research Institute of Pulmonology, Federal Biomedical Agency
期: 卷 82, 编号 11 (2010)
页面: 15-18
栏目: Editorial
##submission.dateSubmitted##: 09.04.2020
##submission.datePublished##: 15.11.2010
URL: https://ter-arkhiv.ru/0040-3660/article/view/30696
ID: 30696

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Aim. To study the outcomes of severe pandemic influenza A/H1N1/2009.
Subjects and methods. The study enrolled 24 patients, including 8 males and 16 females (10 of whom were pregnant), aged 17 to 58 years, with a laboratorily verified diagnosis of pandemic influenza A/H1N1/2009, treated at the intensive care unit for the significant symptoms of acute respiratory failure (RF). Real-time RT-PCR was used to verify the diagnosis. Organs and tissues from deceased patients were histologically studied; chest computed tomography, body plethysmography, fibrobronchoscopy, breath test, and 6-minute walk test were performed in the late period.
Results. Within the first 30 days, a fatal outcome caused by therapy-resistant progressive RF was observed in 33% of the patients with pandemic influenza treated at the intensive care unit. Diffuse alveolar damage caused by influenza virus, which gives rise to hyaline membranes, underlies RF. Lung tissue fibrosis formed in recovered patients.
Conclusion. The severity of pandemic influenza A/H1N1/2009 was determined by massive bilateral pneumonia, interstitial (alveolar) pulmonary edema, formation of diffuse bilateral lung fibrosis at the outcome of severe virus pneumonia (acute respiratory distress syndrome) with a decrease in vital and diffusing capacities, thereby generating a need to follow up this patient category and, possibly, to elaborate special rehabilitation programs.

关键词

influenza, pandemic, acute respiratory distress syndrome, diffuse alveolar damage, lung fibrosis

参考

Онищенко Г. Г. Эпидемическая ситуация по гриппу, вызванному высокопатогенным вирусом типа A(H1N1) в Российской Федерации и в мире. Журн. микробиол. 2010; 1: 3-9.
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CDC news conference with Thomas R. Frieden, Centers for Disease Control and Prevention, Dec. 10, 2009. CDC web site, "CDC Estimates of 2009 H1N1 Influenza Cases, Hospitalizations and Deaths in the United States, April-November 14, 2009", Dec. 10, 2009. http:flu.gov/individualfamily/about/ h1n1/estimates_2009_h1n1.html.
CDC estimates of 2009 H1N1 influenza cases, hospitalizations and deaths in the United States, April 2009-February 13, 2010. Atlanta: Centers for Disease Control and Prevention, 2010. (Accessed April 9, 2010, at http://flu.gov/individualfamily/about/h1n1/estimates_2009_h1n1.html).
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Jamieson D. J., Honein M. A., Rasmussen S. A. et al. H1N1 2009 influenza virus infection during pregnancy in the USA. Lancet 2009; 374: 451-458.
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Outcomes of severe pandemic influenza A/H1N1/2009

全文:

详细

关键词

作者简介

Elena Klimova

Nikolay Yushchuk

Galina Karetkina

Pavel Boytsov

Avet Serobyan

Elena Kelli

Nikolay Malyshev

Natal'ya Golokhvastova

Madina Esaulova

Natal'ya Karchevskaya

Sergey Avdeev

E Klimova

N Yushchuk

G Karetkina

P Boitsov

A Serobyan

E Kelli

N Malyshev

N Golokhvastova

M Esaulova

N Karchevskaya

S Avdeyev

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