Clinicoinstrumental AND laboratory characteristics of early stages of gonarthrosis
- 作者: Svetlova M.S.1, Vezikova N.N.1, Svetlova MS2, Vezikova NN2
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隶属关系:
- Department of Hospital Therapy, Petrozavodsk State University, Federal Agency for Education
- 期: 卷 82, 编号 5 (2010)
- 页面: 54-58
- 栏目: Editorial
- ##submission.dateSubmitted##: 09.04.2020
- ##submission.datePublished##: 15.05.2010
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30604
- ID: 30604
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Subjects and methods. Three hundred and eight female and male patients with early stages of gonarthrosis and 50 healthy individuals were examined. Clinical, X-ray, and arthrosonographic studies were performed; the levels of interleukin (IL) 1β, IL-1B receptor antagonist, and IL-6 were measured and quality of life was assessed.
Results. The findings have led to the conclusion that the early stages of gonarthrosis are characterized by significant clinical symptomatology and lower femur condylar cartilage height; synovitis is frequently revealed by arthrosonography; there is IL-1β hyperproduction; the quality of life in the patients is worse than that in the healthy individuals from the control group.
Conclusion. Therapy aimed at alleviating the symptoms of gonarthrosis and local inflammation and reducing the rate of articular cartilage degradation and X-ray progression of the disease should be initiated at the earliest, including pre-X-ray, stages of the pathological process.
作者简介
Marina Svetlova
Email: svetlovam@rabmler.ru
Natal'ya Vezikova
Email: vezicov23@mail.ru
M Svetlova
Department of Hospital Therapy, Petrozavodsk State University, Federal Agency for EducationDepartment of Hospital Therapy, Petrozavodsk State University, Federal Agency for Education
N Vezikova
Department of Hospital Therapy, Petrozavodsk State University, Federal Agency for EducationDepartment of Hospital Therapy, Petrozavodsk State University, Federal Agency for Education
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