Antithyroid antibodies of varying specificity in the pathogenesis and diagnosis of autoimmune thyroid diseases
- 作者: Ivanova E.V.1, Bogatyreva Z.I.1, Isaeva M.A.1, Suchkova EN1, Baysugurov MA1, Andreeva A.V.1, Korotkova A.A.1, Notkins A1, Pal'tsev M.A.1, Suchkov S.V.1, Ivanova EV1, Bogatyreva ZI1, Isayeva MA1, Suchkova EN1, Baisugurov MA1, Andreyeva AV1, Korotkova AA1, Notkins A1, Paltsev MA1, Suchkov SV1
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隶属关系:
- 期: 卷 81, 编号 10 (2009)
- 页面: 39-45
- 栏目: Editorial
- ##submission.dateSubmitted##: 09.04.2020
- ##submission.datePublished##: 15.10.2009
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30523
- ID: 30523
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Materials and methods. The sera from 240 patients with autoimmune thyroiditis (AIT) and from 124 with diffuse toxic goiter (DTG) were examined. The sera from 40 healthy donors served as a control. The sera were screened for anti-TG and anti-TPO autoAB, anti-TGPO autoAB, by employing enzyme immunoassay and/or radioimmunoassay. The results were statistically processed using the variation statistics-based programs.
Results. The specific features of an autoantigenic component to thyroid tissues were found in the sera of patients with AIT and DTG. An association was established between the progression of disease and the phasic change of autoAB populations or their combinations.
Conclusion. The procedure for evaluating seropositivity for antithyroid autoAB, which is referred to as non-invasive studies, can be considered as a criterion test in the diagnosis and prediction of the course of AIT and DTG.
作者简介
Evgeniya Ivanova
Email: iva0577@mail.ru
Zemfira Bogatyreva
Marina Isaeva
Email: isaeva_marina@bk.ru
E Suchkova
M Baysugurov
Anna Andreeva
Anastasiya Korotkova
Email: fleur@andyone.in
A Notkins
Email: anotkins@mail.nih.gov
Mikhail Pal'tsev
Email: stepanova@mmascience.ru
Sergey Suchkov
Email: ssuchkov@online.ru
E Ivanova
Z Bogatyreva
M Isayeva
E Suchkova
M Baisugurov
A Andreyeva
A Korotkova
A Notkins
M Paltsev
S Suchkov
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