电邮这篇文章 Immunological features of rheumatoid arthritis in patients infected withviruses of hepatitis В, С and cryoglobulinemia
- 作者: Balabanova RM1, Shekshina ЕV1, Kozlov LV1
-
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- 期: 卷 79, 编号 11 (2004)
- 页面: 74-77
- 栏目: Editorial
- ##submission.dateSubmitted##: 09.04.2020
- ##submission.datePublished##: 15.11.2004
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29963
- ID: 29963
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Aim. To specify immunological features of rheumatoid arthritis (RA) associated with hepatitis В, С viruses
(HBV, HCV) and cryoglobulinemia (CGE).
Material and methods. Four groups of patients with verified RA were examined immunologically: infected
with HCV, infected with HBV, with CGE diagnosed by the capillary method, free of HBV,
HCV, CGE. CGE was estimated by the spectrophotometry method, functional activity of the complement
components - by hemolytic micromethod. Polymerase chain reaction, identification of serological
markers of viral hepatitides В and С were conducted with application of commercial kits produced
in Russia
Results. In RA patients infected with HBV and HCV, functional activity of the complement was significantly
reduced. RA patients with hepatitis С and CGE showed hypoactivity of all the complement
components. A classic course of RA was associated with elevated levels of CI and C3 components in
normal values of Clq, C2, C4 and C5 components. CGE was highest in RA+HCV and RA+CGE
groups.
Conclusion. The study of immunological features of RA associated with HCV, HBV and CGE is important
not only in scientific but also in practical aspect as it indicates the necessity of treating the
above conditions with drugs which do not suppress complement system significantly.
(HBV, HCV) and cryoglobulinemia (CGE).
Material and methods. Four groups of patients with verified RA were examined immunologically: infected
with HCV, infected with HBV, with CGE diagnosed by the capillary method, free of HBV,
HCV, CGE. CGE was estimated by the spectrophotometry method, functional activity of the complement
components - by hemolytic micromethod. Polymerase chain reaction, identification of serological
markers of viral hepatitides В and С were conducted with application of commercial kits produced
in Russia
Results. In RA patients infected with HBV and HCV, functional activity of the complement was significantly
reduced. RA patients with hepatitis С and CGE showed hypoactivity of all the complement
components. A classic course of RA was associated with elevated levels of CI and C3 components in
normal values of Clq, C2, C4 and C5 components. CGE was highest in RA+HCV and RA+CGE
groups.
Conclusion. The study of immunological features of RA associated with HCV, HBV and CGE is important
not only in scientific but also in practical aspect as it indicates the necessity of treating the
above conditions with drugs which do not suppress complement system significantly.
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