Email this article Iodine prophylaxis in pregnant women: a comparativeanalysis of different methods efficacy in conditions of goiter endemia
- Authors: Turovinina ЕF1, Suplotova LA1, Khramova EВ1, Smetanina SA1
-
Affiliations:
- Issue: Vol 78, No 10 (2003)
- Pages: 54-56
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29668
- ID: 29668
Cite item
Full Text
Abstract
Aim. To assess efficacy of different methods of iodine prophylaxis in pregnant women living in conditions of goiter endemia.
Material and methods. Standard clinical, laboratory and device tests for iodine deficiency according
to WHO criteria were made in 156 pregnant women living in the territory affected by goiter endemia.
Of them, 121 examinees had no thyroid pathology, 35 ones had diffuse euthyroid goiter. All of them
received different kinds of iodine prophylaxis.
Results. The occurrence of neonatal TTH values over 5 iU/l in neonates born by mothers free of thyroid pathology on potassium iodide prophylaxis when pregnant was 9.1%. This is much lower than in
conventional iodine prophylaxis - 17.24% (p < 0.01). A comparative analysis of the efficacy of potassium iodide-200 in pregnant women with diffuse euthyroid goiter and its combination with L-thy
roxin has shown that by the effect on lessening frequency of neonatal ТТЯ over 5 Ш/l the above
schemes do not differ significantly, thyroid reduction is more prominent in pregnant women on thyroxine with potassium iodide.
Conclusion. The index of neonatal TTH is an objective criterium to control efficacy of different methods of iodine prophylaxis in pregnancy.
Material and methods. Standard clinical, laboratory and device tests for iodine deficiency according
to WHO criteria were made in 156 pregnant women living in the territory affected by goiter endemia.
Of them, 121 examinees had no thyroid pathology, 35 ones had diffuse euthyroid goiter. All of them
received different kinds of iodine prophylaxis.
Results. The occurrence of neonatal TTH values over 5 iU/l in neonates born by mothers free of thyroid pathology on potassium iodide prophylaxis when pregnant was 9.1%. This is much lower than in
conventional iodine prophylaxis - 17.24% (p < 0.01). A comparative analysis of the efficacy of potassium iodide-200 in pregnant women with diffuse euthyroid goiter and its combination with L-thy
roxin has shown that by the effect on lessening frequency of neonatal ТТЯ over 5 Ш/l the above
schemes do not differ significantly, thyroid reduction is more prominent in pregnant women on thyroxine with potassium iodide.
Conclusion. The index of neonatal TTH is an objective criterium to control efficacy of different methods of iodine prophylaxis in pregnancy.
References
- Касаткина Э. П., Шияин Д. Е., Петрова Л. М. и др. Роль йодного обеспечения в неонатальной адаптации тиреоидной системы. Пробл. эндокринол. 2001; 3: 10-15.
- Губина В. В. Роль скрининга врожденного гипотиреоза в изучении эпидемиологии йоддефицитных заболеваний: Автореф. дис. канд. мед. наук. - М.; 1999. 19-20.
- WHO: Indicators for assessing iodine deficiency disorders and their control programmes. Report of a joint WHO/UNICEF/ ICCIDD consultation, September. 1993.
- Delange-F. Neonatal thyroid screening as a monitoring tool for the control of iodine deficiency. ICCIDD, Brussels, Belgium. Acta Paediatr. 1999;8S (suppl. 432): 21-24.
- Трифонова И. Ю. Йодное обеспечение и последствия дефицита йода у детей в условиях зобной эндемии средней степени тяжести: Автореф. дис. канд. мед. наук. Красноярск; 2001. 8-11.
- Бурумкулова Ф. Ф., Герасимов Г. А. Заболевания щитовидной железы и беременность. Пробл. эндокринол. 1998; 2: 27-32.
- Мельниченко Г. А., Мурашко Л. Е., Малясоеа С. В. Заболевание щитовидной железы и беременность. Рос. мед. журн. 1999; 3: 10-12 .
Supplementary files
