Email this article CHANGES IN ADAPTATION-COMPENSATION PROCESSES IN THE COURSE OF ACUTEISCHEMIC STROKE (CLINICOBIOCHEMICAL CORRELATIONS)
- Authors: Matsko MA1, Ivanovа NE1
-
Affiliations:
- Issue: Vol 78, No 8 (2003)
- Pages: 78-81
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/33404
- ID: 33404
Cite item
Full Text
Abstract
Aim. To study changes in some components of stress-realizing system (SRS) and stress-limiting system
(SLS) characterizing compensatory mechanisms in acute disturbance of cerebral circulation (ADCC).
Material and methods. The activities of SRS and SLS were assessed in 94 patients by changes in the
concentrations of glutamate, aspartate, acid phosphatase for SRS and gamma-aminobutyric acid
(GABA) for SLS, respectively.
Results. After analysis of clinicobiochemical correlations the following clinical phases were singled out:
subcompensation, moderate decompensation, severe decompensation and terminal. The phase conversion
depended on quantitative changes of SRS and SLS activity. This enabled characterization of severity
in certain time periods. Imbalance was revealed between SRS and SLS because of hyperactivation
or hypoactivation of one of the above systems.
Conclusion. Imbalance between SRS and SLS converts stress-syndrome from nonspecific link of adaptation
into a nonspecific link of the disease pathogenesis.
(SLS) characterizing compensatory mechanisms in acute disturbance of cerebral circulation (ADCC).
Material and methods. The activities of SRS and SLS were assessed in 94 patients by changes in the
concentrations of glutamate, aspartate, acid phosphatase for SRS and gamma-aminobutyric acid
(GABA) for SLS, respectively.
Results. After analysis of clinicobiochemical correlations the following clinical phases were singled out:
subcompensation, moderate decompensation, severe decompensation and terminal. The phase conversion
depended on quantitative changes of SRS and SLS activity. This enabled characterization of severity
in certain time periods. Imbalance was revealed between SRS and SLS because of hyperactivation
or hypoactivation of one of the above systems.
Conclusion. Imbalance between SRS and SLS converts stress-syndrome from nonspecific link of adaptation
into a nonspecific link of the disease pathogenesis.
References
- Бердичееский М. Я., Сторожук П. Г. Значение исследования некоторых эритроцитарных ферментов в определении характера инсульта в острейшем периоде. Журн. невропатол. и психиатр. 1990; 10: 29-31.
- Крыжановский Г. Н. Общая патофизиология нервной системы. М: Медицина; 1997. 350.
- Лукьянова Л. Д. Фармакологическая коррекция гипоксических состояний. М.; 1991. 11-44.
- Лукьянова Л. Д. Биоэнергетическая гипоксия: понятие, механизмы и способы коррекции. Бюл. экспер. биол. 1997; 9: 244-254.
- Меерсон Ф. З. Стресс-лимитирующие системы организма и их роль в предупреждении ишемических повреждений сердца. Бюл. Всесоюз. кардиол. науч. центра 1985; 1:34- 43.
- Суслина З. А., Гераскина Л. А. Проблемы лечения ишемического инсульта. Клин, фармакол. и тер. 1996; 5: 80-83.
- Коновалов А. Н., Самотокин Б. А., Васин Н. А., Лихтермт Л. Б. Градации тяжести состояния пострадавших с черепно-мозговой травмой и унифицированные критерии для их определения. Вопр. нейрохир. 1982; 5: 11 - 16.
- Нарциссов С. А. Определение оксидоредуктаз гистохимическим методом. Пат. анат. 1969; 5: 85-91.
- Pearson S. S., Crudek С., Mercer К., Reynolds G. P. J. Neural Transm. 1991; 86: 151-157
Supplementary files
