Primary immunodeficiency in adults: total variable immune deficiency clinical manifestations, immunological and genetic defects, treatment


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Abstract

The most prevalent form of primary immunodeficiency with a total defect of antibody production in adults is common variable immunodeficiency (CVID). Compared to other forms of primary immunodeficiency, CVID is characterized by later onset of clinical manifestations represented by infectious, autoimmune and malignant diseases. To avoid development of complications and patient incapacitating, it is necessary to make an early diagnosis and initiate regular replacement therapy with intravenous immunoglobulins.

About the authors

Aleksandr Viktorovich Karaulov

Email: karaulov@mtu-net.ru

Irina Valentinovna Sidorenko

Vladimir Vladimirovich Androsov

Anna Sergeevna Kapustina

A V Karaulov

I.M. Sechenov First Moscow State Medical University

I.M. Sechenov First Moscow State Medical University

I V Sidorenko

I.M. Sechenov First Moscow State Medical University

I.M. Sechenov First Moscow State Medical University

V V Androsov

City hospital N 7, Moscow

City hospital N 7, Moscow

A S Kapustina

I.M. Sechenov First Moscow State Medical University

I.M. Sechenov First Moscow State Medical University

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