The level of endothelin-1 and reactivity of skin microvessels in patients with early stages of chronic kidney disease
- Authors: Smirnov A.V.1, Petrishchev N.N.1, Panina I.Y.1, Mnuskina M.M.1, Achkasova V.V.1, Rumyantsev A.S.1, Menshutina M.A.1, Smirnov AV2, Petrischev NN2, Panina IY.2, Mnuskina MM2, Achkasova VV2, Rumyantsev AS.2, Menshutina MA2
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Affiliations:
- I.P. Pavlov State Medical University, St. Petersburg
- Issue: Vol 83, No 6 (2011)
- Pages: 13-18
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30834
- ID: 30834
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Full Text
Abstract
Material and methods. Glomerular filtration rate (GFR) was calculated by MDRD formula for 40 healthy subjects (mean age 39.2±2.0 years) and 147 CKD patients (mean age 41.4±1.8 years). All the patients were also exposed to the cold test (a modified variant).
Results. Patients with CKD stage I demonstrated a 35.1% fall in blood flow rate (Qas) in response to cold stimulus, patients of stage II - a 42.2% fall, healthy patients - a 19.3%. CKD patients of stage I and II retained a Qas fall for 3 min after exposure to cold, while healthy subjects resumed skin blood circulation immediately after exposure to cold. Blood plasma ET-1 concentration in healthy subjects was 0.239±0.055 fmol/ml, in stage I CKD patients - 0.334±0.066 fmol/l, in stage II CKD patients - 0.422±0.041 fmol/l. Relationships were found between ET-1 level and GFR (Rs = 0.242; p < 0.05), 24 h proteinuria (Rs = 0.375; p < 0.003) and Qas% in the cold test (Rs = -0.389; p < 0.003) as well as time of recovery of the background Qas (Rs = -0.311; p < 0.003).
Conclusion. Dysfunction of autonomic nervous system at early stages of CKD may arise by means of activation of ET-1 synthesis in response to enhancement of sympathetic impacts.
About the authors
Aleksey Vladimirovich Smirnov
Email: smirnov@nephrolog.ru
Nikolay Nikolaevich Petrishchev
Email: lasmed@yandex.ru
Iraida Yur'evna Panina
Email: i.u.panina@mail.ru
Marina Mikhaylovna Mnuskina
Email: marina-gkdc@rambler.ru
Vera Vladimirovna Achkasova
Email: kirjasha@mail.ru
Aleksandr Shalikovich Rumyantsev
Email: rash.56@mail.ru
Mariya Alekseevna Menshutina
Email: menshutina@mail.ru
A V Smirnov
I.P. Pavlov State Medical University, St. PetersburgI.P. Pavlov State Medical University, St. Petersburg
N N Petrischev
I.P. Pavlov State Medical University, St. PetersburgI.P. Pavlov State Medical University, St. Petersburg
I Yu Panina
I.P. Pavlov State Medical University, St. PetersburgI.P. Pavlov State Medical University, St. Petersburg
M M Mnuskina
I.P. Pavlov State Medical University, St. PetersburgI.P. Pavlov State Medical University, St. Petersburg
V V Achkasova
I.P. Pavlov State Medical University, St. PetersburgI.P. Pavlov State Medical University, St. Petersburg
A Sh Rumyantsev
I.P. Pavlov State Medical University, St. PetersburgI.P. Pavlov State Medical University, St. Petersburg
M A Menshutina
I.P. Pavlov State Medical University, St. PetersburgI.P. Pavlov State Medical University, St. Petersburg
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