Email this article Features of clinical symptoms and course of systemic sclerosis specific for sex and age of onset
- Authors: Volkov AV1, Starovoitova MN1, Guseva NG1
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Affiliations:
- Issue: Vol 79, No 5 (2004)
- Pages: 7-11
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29781
- ID: 29781
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Abstract
Aim. To define clinical features of systemic sclerosis (SS) in age and sex aspects. Material and methods. The study covered 100 patients aged 15 to 83 years with SS (24 males and 76 females) lasting for 1-15 years (mean 6.2 ± 4.1 years). Groups of females and males, with disease onset age under 50 years (32 years) and over 50 years were compared.
Results. Males had a prevalent diffuse clinical form ofSS with advanced skin syndrome, primarily indurative alterations, marked disturbances of microcirculation, abnormal heart rhythm and conduction, interstitial pulmonary fibrosis with development of pulmonary hypertension. The patients with late SS onset are characterized by development of visceral pathology within the first 3 years of the disease. Conclusion. In making SS diagnosis and in the disease treatment it is necessary to consider the patients ' sex and age, peculiarities of the debute, clinical picture, course and prognosis.
Results. Males had a prevalent diffuse clinical form ofSS with advanced skin syndrome, primarily indurative alterations, marked disturbances of microcirculation, abnormal heart rhythm and conduction, interstitial pulmonary fibrosis with development of pulmonary hypertension. The patients with late SS onset are characterized by development of visceral pathology within the first 3 years of the disease. Conclusion. In making SS diagnosis and in the disease treatment it is necessary to consider the patients ' sex and age, peculiarities of the debute, clinical picture, course and prognosis.
References
- Гусева Н. Г. Системная склеродермия и псевдосклеродермические синдромы. М.: Медицина; 1993.
- Jayson M. A., Black С. М. Systemic sclerosis: scleroderma. New York: John Willey & Sons Ltd.; 1988.
- Ferri C., Bernini L., Cecchetti R. et al. Cutaneous and serologic subsets of systemic sclerosis. J. Rheumatol. 1991; 18: 1826- 1832.
- Гусева Н. Г. 40 лет изучения системной склеродермии (по данным Института ревматологии РАМН). Вестн. РАМН 1998; 12: 27-29.
- Nishioka К., Katayama I., Kondo H. et al. Epidemiological analysis of prognosis of 496 Japanese patients with progressive systemic sclerosis (SSc). Scleroderma Research Committee Japan. J. Dermatol. 1996; 23 (10): 677-682.
- Старовойтова М. Н. Ювенильная системная склеродермия: Автореф. дис. ... канд. мед. наук. М.; 1997.
- Czirjak L., Nagy Z., Szegedi G. Systemic sclerosis in the elderly. Clin. Rheumatol. 1992; 11 (4): 483-485.
- Williams P. L., Gumpel J. M. Scleroderma in the elderly. Br. Med. J. (Clin. Res. Ed.) 1981; 282 (6268): 948.
- Stafford L., Englert H., Gover J. et al. Distribution of macrovascular disease in scleroderma. Ann. Rheum. Dis. 1998; 57 (8): 476-479.
- Youssef P., Brama Т., Englert H. et al. Limited scleroderma is associated with increased prevalence of macrovascular disease. J. Rheumatol. 1995; 22 (3): 469-472.
- Котелышкова Г. П., Гусева Н. Г. Эхокардиографическое изучение состояния сердца при ССД. Тер. арх. 1986; 12: 87-91.
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