Email this article Results of a multicenter trial "Epidemiology of Gastroesophageal Reflux Disease in Russia" (MEGRE)
- Authors: Lazebnik L.B.1, Masharova A.A.1, Bordin D.S.1, Vasil'ev Y.V.1, Tkachenko E.I.1, Abdulkhakov R.A.1, Butov M.A.1, Eremina E.Y.1, Zinchuk L.I.1, Tsukanov V.V.1, Lazebnik LB2, Masharova AA2, Bordin DS2, Vasiliev Y.V2, Tkachenko EI3, Abdulkhakov RA4, Butov MA5, Eremina EY.6, Zinchuk LI7, Tsukanov VV8
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Affiliations:
- Central Research Gastroenterological Institute, Moscow
- I.I. Mechnikov St-Petersburg State medical Academy
- State Medical University, Kazan
- I.P. Pavlov State Medical University, Ryazan
- N.P. Ogarev Mordovian State University, Saransk
- State Medical Academy, Kemerovo
- Research Institute of North Medical Problems of the Russian Academy of Medical Sciences, Krasnoyarsk
- Issue: Vol 83, No 1 (2011)
- Pages: 45-50
- Section: Editorial
- Submitted: 10.04.2020
- Published: 15.01.2011
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30789
- ID: 30789
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Abstract
Material and methods. Mayo Clinic questionnaire (USA) adapted for Russia was used to question 7812 people over 18 years of age from of random population sample. The symptoms (heartburn and regurgitation) were classified as frequent if they arose once a week and more often for the last 12 months, rare symptoms arose less often than once a week. The responders with frequent heartburn and/or regurgitation were regarded as persons with epidemiological quantitative criteria of GERD.
Results. Heartburn occurred in 47.5% responders: frequent in 9%, rare in 38.5%. Regurgitation occurred in 42.9%: frequent in 7.6%, rare in 35.3%. GERD prevalence was 13.3% (city range 11.3-14.3%). Frequent GERD symptoms are associated with frequent gaseous eructation (24.3%), chronic cough (22.9%), chest pain (15.1%), dysphonia (11.4%.). To stop heartburn, 88% responders took antacids, 32% - blockers of histamine H2-receptors and only 23% - inhibitors of proton pump. Only 52.8% responders with frequent chest pain and 29.3% those with frequent hearburn visited a doctor.
Conclusion. The population-based trial MEGRE conducted by international methodology in 6 cities of Russia demonstrated that GERD prevalence is 13.3%. Most of the patients pay little attention to the symptoms, do not seek medical advice and, therefore, receive no adequate treatment.
Keywords
About the authors
Leonid Borisovich Lazebnik
Antonina Aleksandrovna Masharova
Email: a.masharova@gmail.com
Dmitriy Stanislavovich Bordin
Email: dbordin@mail.ru
Yuriy Vasil'evich Vasil'ev
Email: gastroenter@rambler.ru
Evgeniy Ivanovich Tkachenko
Email: tkachenkoe @mail.ru
Rustem Abbasovich Abdulkhakov
Email: rustemabdul@mail.ru
Mikhail Aleksandrovich Butov
Email: butov-m@yandex.ru
Elena Yur'evna Eremina
Email: eeu61@mail.ru
Lyudmila Ivanovna Zinchuk
Email: gospitter@yandex.ru
Vladislav Vladimirovich Tsukanov
Email: rsimpn@scn.ru
L B Lazebnik
Central Research Gastroenterological Institute, MoscowCentral Research Gastroenterological Institute, Moscow
A A Masharova
Central Research Gastroenterological Institute, MoscowCentral Research Gastroenterological Institute, Moscow
D S Bordin
Central Research Gastroenterological Institute, MoscowCentral Research Gastroenterological Institute, Moscow
Yu V Vasiliev
Central Research Gastroenterological Institute, MoscowCentral Research Gastroenterological Institute, Moscow
E I Tkachenko
I.I. Mechnikov St-Petersburg State medical AcademyI.I. Mechnikov St-Petersburg State medical Academy
R A Abdulkhakov
State Medical University, KazanState Medical University, Kazan
M A Butov
I.P. Pavlov State Medical University, RyazanI.P. Pavlov State Medical University, Ryazan
E Yu Eremina
N.P. Ogarev Mordovian State University, SaranskN.P. Ogarev Mordovian State University, Saransk
L I Zinchuk
State Medical Academy, KemerovoState Medical Academy, Kemerovo
V V Tsukanov
Research Institute of North Medical Problems of the Russian Academy of Medical Sciences, KrasnoyarskResearch Institute of North Medical Problems of the Russian Academy of Medical Sciences, Krasnoyarsk
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