Long-term results of coronary endovascular revascularisation with eluting sirolimus-stents in patients with coronary heart disease comorbid with type-2 diabetes mellitus: evidence from 18-month prospective study
- Authors: Teplyakov AT1, Torim Y.Y.1, Kuznetsova AV1, Rybal'chenko EV1, Krylov AL1, Karpov RS1, Teplyakov AT1, Torim Y.Y.1, Kuznetsova AV1, Rybalchenko EV1, Krylov AL1, Karpov RS1
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Affiliations:
- Issue: Vol 81, No 5 (2009)
- Pages: 54-59
- Section: Editorial
- Submitted: 09.04.2020
- Published: 15.05.2009
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30347
- ID: 30347
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Abstract
Material and methods. A total of 108 CHD patients with angina pectoris resistant to antianginal therapy were divided into 2 groups: 51 CHD patients with mild and moderate type-2 DM (group 1); 57 CHD patients free of diabetus (group 2). All the patients have undergone successful coronary endovascular revascularisation with SES. Anti-ischemic efficacy and safety of stenting were studied in the course of 18-month prospective follow-up.
Results. An anti-ischemic effect of stenting in hospital setting was achieved in all the patients. 18 months after stenting frequency and severity of anginal attacks reduced in group 1 by 70.6%, daily need in nitroglicerine - by 71.9%, in group 2 - by 87.1 and 93.1%, respectively. As a result, exercise tolerance improved in group 1 by 38.3%, in group 2 - by 40.8%. Quality of life improved by 22.7 and 25.1%, respectively. Most of the patients showed no deterioration of carbohydrate and lipid metabolism compensation. Recurrent angina and symptoms of painless myocardial ischemia occurred in 39.3 and 14% patients of group 1 and 2, respectively. More frequent causes of the recurrence were progression of coronary artery atherosclerosis de novo and Cypher stent restenosis (11.8 and 3.5% in group 1 and 2, respectively).
Conclusion. SES implantation provided good anti-ischemic efficacy in 60.7 and 86% CHD patients with and without DM, respectively. It significantly improved exercise tolerance and quality of life.
About the authors
A T Teplyakov
Yu Yu Torim
A V Kuznetsova
E V Rybal'chenko
A L Krylov
R S Karpov
A T Teplyakov
Yu Yu Torim
A V Kuznetsova
E V Rybalchenko
A L Krylov
R S Karpov
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