The experience of using the Russian biosimilar of the original drug eculizumab for the treatment of patients with atypical hemolytic-uremic syndrome

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Abstract


Atypical hemolytic-uremic syndrome (aHUS) is a chronic systemic disease of a genetic nature, which is based on uncontrolled activation of the alternative complement pathway, leading to generalized thrombosis in the vessels of the microvasculature (complement-mediated thrombotic microangiopathy). To date, therapy with eculizumab is the most effective and pathogenetically substantiated method of treating patients with ASH. Using the example of three clinical cases of patients with a verified diagnosis of aHUS, the high efficiency and safety of the world’s first bioanalogue of eculizumab in the treatment of adult patients with aHUS (complement-mediated thrombotic microangiopathy) was demonstrated.


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About the authors

Yulia V. Lavrishcheva

Almazov National Medical Research Centre

Author for correspondence.
Email: lavrischeva@gmail.com
ORCID iD: 0000-0002-3073-2785

Russian Federation, Moscow

врач-нефролог

Alexander A. Yakovenko

Pavlov First Saint Petersburg State Medical University

Email: lavrischeva@gmail.com
ORCID iD: 0000-0003-1045-9336

Russian Federation, Moscow

канд. мед. наук, доц. каф. нефрологии и диализа

Dmitrii A. Kudlai

JSC GENERIUM

Email: lavrischeva@gmail.com

Russian Federation, Moscow

д-р мед. наук, ген. дир.

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