Successful treatment of a rare variant of mesangioproliferative glomerulonephritis with IgM deposits with Cyclosporin A

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We present a case with a rare variant of glomerulonephritis, IgM nephropathy, which occurs mainly with nephrotic syndrome. The clinical features of this variant of kidney damage are characterized; the pathogenetic and the transformation of this form of nephritis into focal segmental glomerulosclerosis are discussed. The development of severe nephrotic syndrome at the beginning of the disease, the formation of secondary steroid resistance have confirmed this hypothesis and have justified the treatment with cyclosporin A aimed at the recovery of the function of the podocyte with remission of nephritis.

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About the authors

Daria V. Gurova

Sechenov First Moscow State Medical University (Sechenov University)

ORCID iD: 0000-0001-8232-3679

Russian Federation, Moscow

студентка, Клиника им. Е.М. Тареева

Natalia V. Chebotareva

Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
ORCID iD: 0000-0003-2128-8560

Russian Federation, Moscow

д.м.н., проф., каф. внутренних, профессиональных болезней и ревматологии, Клиника им. Е.М. Тареева

Anatoliy A. Vinogradov

Lomonosov Moscow State University

ORCID iD: 0000-0001-7529-0215

Russian Federation, Moscow

клинический ординатор каф. внутренних болезней

Ekaterina V. Stavrovskaya

Sechenov First Moscow State Medical University (Sechenov University)


Russian Federation, Moscow

доц. каф. внутренних, профессиональных болезней и ревматологии, Клиника им. Е.М. Тареева

Lidia V. Lysenko

Sechenov First Moscow State Medical University (Sechenov University)


Russian Federation, Moscow

д.м.н. проф., каф. внутренних, профессиональных болезней и ревматологии, Клиника им. Е.М. Тареева


  1. Cohen AH, Border WA, Glassock RJ. Nehprotic syndrome with glomerular mesangial IgM deposits. Lab Invest. 1978;38(5):610-9. PMID: 347169.
  2. Bhasin HK, Abuelo JG, Nayak R, Esparza AR. Mesangial proliferative glomerulonephritis. Lab Invest. 1978;39(1):21-9. PMID: 355724.
  3. Myllymäki J, Saha H, Mustonen J, et al. IgM nephropathy: clinical picture and long-term prognosis. Am J Kidney Dis. 2003;41(2):343-50. doi: 10.1053/ajkd.2003.50042
  4. Little MA, Dorman A, Gill D, Walshe JJ. Mesangioproliferative glomerulonephritis with IgM deposition: clinical characteristics and outcome. Ren Fail. 2000;22(4):445-57. doi: 10.1081/jdi-100100886
  5. Mubarak M. IgM nephropathy. Indian J Pediatr. 2013;80(4):357. doi: 10.1007/s12098-012-0816-7
  6. Singhai AM, Vanikar AV, Goplani KR, et al. Immunoglobulin M nephropathy nephropathy in adults and adolescents in India: a single-center study of natural history. Indian J Pathol Microbiol. 2011;54(1):3-6. doi: 10.4103/0377-4929.77315
  7. Connor TM, Aiello V, Griffith M, et al. The natural history of immunoglobulin M nephropathy in adults. Nephrol Dial Transplant. 2017;32(5):823-9. doi: 10.1093/ndt/gfw063
  8. Mokhtar GA. IgM nephropathy: clinical picture and pathological findings in 36 patients. Saudi J Kidney Dis Transpl. 2011;22(5):969-75.
  9. Disciullo SO, Abuelo JG, Moalli K, Pezzullo JC. Circulating heavy IgM in IgM nephropathy. Clin Exp Immunol. 1988;73(3):395-400. PMID: 3145162. PMCD: pmc1541770
  10. Lin CY, Chen CH, Lee PP. In vitro B-lymphocyte switch disturbance from IgM into IgG in IgM mesangial nephropathy. Pediatr Nephrol. 1989;3(3):254-8. doi: 10.1007/bf00858525
  11. Strassheim D, Renner B, Panzer S, et al. IgM contributes to glomerular injury in FSGS. J Am Soc Nephrol. 2013;24(3):393-406. doi: 10.1681/ASN.2012020187
  12. Grönwall C, Vas J, Silverman GJ. Protective Roles of Natural IgM Antibodies. Front Immunol. 2012;3:66. doi: 10.3389/fimmu.2012.00066
  13. Vanikar A. IgM nephropathy; can we still ignore it. J Nephropathol. 2013;2(2):98-103. doi: 10.12860/JNP.2013.16
  14. Mubarak M, Kazi JI. IgM nephropathy revisited. Nephrourol Mon. 2012;4(4):603-8. doi: 10.5812/numonthly.2805
  15. Salmon AH, Kamel D, Mathieson PW. Recurrence of IgM nephropathy in a renal allograft. Nephrol Dial Transplant. 2004;19(10):2650-2. doi: 10.1093/ndt/gfh434
  16. Westphal S, Hansson S, Mjörnstedt L, et al. Early recurrence of nephrotic syndrome (immunoglobulin m nephropathy) after renal transplantation successfully treated with combinations of plasma exchanges, immunoglobulin, and rituximab. Transplant Proc. 2006;38(8):2659-60. doi: 10.1016/j.transproceed.2006.07.034
  17. Border WA. Distinguishing minimal-change disease from mesangial disorders. Kidney Int. 1988;34(3):419-34. doi: 10.1038/ki.1988.197



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