Changes in metabolic parameters and glomerular filtration rate in patients with morbid obesity after bariatric surgery

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Abstract


Aim. To study the effect of weight loss in the short term after bariatric surgery (BO) on metabolic parameters and glomerular filtration rate (GFR) in patients with morbid obesity.

Materials and methods. We studied 40 adult (over 18 years) patients with morbid obesity who underwent bariatric surgery. Metabolic indices and calculated GFR according to the CKD-EPI formula in patients before and after bariatric surgery were compared.

Results. In the whole group of operated patients, the average body mass index (BMI) after surgery decreased from 45.8 to 30.5 kg/m2. In 11 (92%) patients with impaired carbohydrate metabolism, remission of diabetes mellitus was achieved and sugar-lowering drugs were canceled. In patients with baseline GFR≥90 ml/min/1.73 m2 after surgery, there is a tendency towards a decrease in GFR, probably due to a decrease in hyperfiltration. In patients with baseline GFR<90 ml/min/1.73 m2 after surgery, a statistically significant increase in the level of GFR was noted. The greater metabolic efficacy of combined operations (mini-gastric bypass, biliopancreatic diversion) in relation to the correction of carbohydrate and fat metabolism was revealed.

Conclusion. Obesity is a modifiable risk factor for decreased kidney function and the progression of chronic kidney disease. Bariatric surgery is an effective treatment for morbid obesity. The study proved the positive effect of weight loss after BO on renal function, including by improving the course of diseases associated with obesity.


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About the authors

Sonya S. Gussaova

Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: gussaova-sonya@mail.ru
ORCID iD: 0000-0002-3886-0669

Russian Federation, Moscow

аспирант каф. внутренних, профессиональных болезней и ревматологии; Клиника ревматологии, нефрологии и профпатологии им. Е.М. Тареева

Irina N. Bobkova

Sechenov First Moscow State Medical University (Sechenov University)

Email: gussaova-sonya@mail.ru
ORCID iD: 0000-0002-8007-5680

Russian Federation, Moscow

д.м.н., проф. каф. внутренних, профессиональных болезней и ревматологии; Клиника ревматологии, нефрологии и профпатологии им. Е.М. Тареева

Yury I. Yashkov

Center for Endosurgery and Lithotripsy

Email: gussaova-sonya@mail.ru
ORCID iD: 0000-0001-6592-1036

Russian Federation, Moscow

д.м.н., врач-хирург

Natalya S. Bordan

Institute of Plastic Surgery and Cosmetology

Email: gussaova-sonya@mail.ru
ORCID iD: 0000-0002-4472-3142

Russian Federation, Moscow

к.м.н., врач-хирург

Ekaterina V. Stavrovskaya

Sechenov First Moscow State Medical University (Sechenov University)

Email: gussaova-sonya@mail.ru
ORCID iD: 0000-0001-6381-2186

Russian Federation, Moscow

к.м.н., доц. каф. внутренних, профессиональных болезней и ревматологии

Dmitry K. Bekuzarov

Center for Endosurgery and Lithotripsy

Email: gussaova-sonya@mail.ru
ORCID iD: 0000-0003-1815-2152

Russian Federation, Moscow

к.м.н., врач-хирург

Vladimir V. Evdoshenko

Institute of Plastic Surgery and Cosmetology

Email: gussaova-sonya@mail.ru

Russian Federation, Moscow

д.м.н., врач-хирург

Vadim V. Fedenko

Institute of Plastic Surgery and Cosmetology

Email: gussaova-sonya@mail.ru
ORCID iD: 0000-0002-1816-384X

Russian Federation, Moscow

д.м.н., врач-хирург

Aleksandra I. Malykhina

Institute of Plastic Surgery and Cosmetology

Email: gussaova-sonya@mail.ru
ORCID iD: 0000-0003-2968-4891

Russian Federation, Moscow

к.м.н., врач-терапевт

Andrey V. Struve

Sechenov First Moscow State Medical University (Sechenov University)

Email: gussaova-sonya@mail.ru
ORCID iD: 0000-0003-0111-2648

Russian Federation, Moscow

студент Международной школы «Медицина будущего» Научно-технологического парка биомедицины

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