Kidney health for everyone everywhere – from prevention to detection and equitable access to care

Cover Page
  • Authors: Kam-Tao Li P.1, Garcia-Garcia G.2, Lui S.3, Andreoli S.4, Wing-Shing Fung W.1, Hradsky A.5, Kumaraswami L.6, Liakopoulos V.7, Rakhimova Z.5, Saadi G.8, Strani L.5, Ulasi I.9, Kalantar-Zadeh K.10
  • Affiliations:
    1. Chinese University of Hong Kong
    2. University of Guadalajara Health Sciences Center
    3. The Chinese University of Hong Kong
    4. Indiana University School of Medicine
    5. World Kidney Day Office
    6. Tanker Foundation
    7. AHEPA Hospital, Aristotle University of Thessaloniki
    8. Cairo University
    9. University of Nigeria
    10. University of California Irvine School of Medicine
  • Issue: Vol 92, No 6 (2020)
  • Pages: 4-14
  • Section: Editorial
  • URL: https://ter-arkhiv.ru/0040-3660/article/view/34973
  • DOI: https://doi.org/10.26442/00403660.2020.06.000545
  • Cite item

Abstract


The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5th most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual healthcare budget in high-income countries. Crucially, however, the onset and progression of CKD is often preventable. In 2020, the World Kidney Day campaign highlights the importance of preventive interventions – be it primary, secondary or tertiary. This complementing article focuses on outlining and analyzing measures that can beimplemented in every country to promote and advance CKD prevention. Primary prevention of kidney disease should focus on the modification of risk factors and addressing structural abnormalities of the kidney and urinary tracts, as well as exposure to environmental risk factors and nephrotoxins. In persons with pre-existing kidney disease, secondary prevention, including blood pressure optimization and glycemic control, should be the main goal of education and clinical interventions. In patients with advanced CKD, management of co-morbidities such as uremia and cardiovascular disease is a highly recommended preventative intervention to avoid or delay dialysis or kidney transplantation. Political efforts are needed to proliferate the preventive approach. While national policies and strategies for non-communicable diseases might be present in a country, specific policies directed toward education and awareness about CKD screening, management and treatment are often lacking. Hence, there is an urgent need to increase the awareness of the importance of preventive measures throughout populations, professionals and policy makers.


Full Text

Restricted Access

About the authors

Philip Kam-Tao Li

Chinese University of Hong Kong

Email: philipli@cuhk.edu.hk

China, Hong-Kong

Carol & Richard Yu PD Research Centre, Prince of Wales Hospital, Department of Medicine and Therapeutics

G. Garcia-Garcia

University of Guadalajara Health Sciences Center

Email: kkz@uci.edu

Mexico, Guadalajara, Jal.

Hospital Civil de Guadalajara Fray Antonio Alcalde, Nephrology Service

S.-F. Lui

The Chinese University of Hong Kong

Email: kkz@uci.edu

China, Hong-Kong

Jockey Club School of Public Health and Primary Care, Division of Health System, Policy and Management

S. Andreoli

Indiana University School of Medicine

Email: kkz@uci.edu

United States, Indianapolis

James Whitcomb Riley Hospital for Children

W. Wing-Shing Fung

Chinese University of Hong Kong

Email: kkz@uci.edu

China, Department of Medicine and Therapeutics

Carol & Richard Yu PD Research Centre, Prince of Wales Hospital, Department of Medicine and Therapeutics

A. Hradsky

World Kidney Day Office

Email: kkz@uci.edu

Belgium, Brussels

L. Kumaraswami

Tanker Foundation

Email: kkz@uci.edu

India, Chennai

V. Liakopoulos

AHEPA Hospital, Aristotle University of Thessaloniki

Email: kkz@uci.edu

Greece, Thessaloniki

Division of Nephrology and Hypertension, 1st Department of Internal Medicine

Z. Rakhimova

World Kidney Day Office

Email: kkz@uci.edu

Belgium, Brussels

G. Saadi

Cairo University

Email: kkz@uci.edu

Egypt, Giza

Nephrology Unit, Department of Internal Medicine, Faculty of Medicine

L. Strani

World Kidney Day Office

Email: kkz@uci.edu

Belgium, Brussels

I. Ulasi

University of Nigeria

Email: kkz@uci.edu

Nigeria, Ituku-Ozalla, Enugu

Renal Unit, Department of Medicine, College of Medicine

K. Kalantar-Zadeh

University of California Irvine School of Medicine

Author for correspondence.
Email: kkz@uci.edu

United States, Orange, CA

Division of Nephrology and Hypertension and Kidney Transplantation

 

References

  1. International Society of Nephrology. 2019 United Nations High Level Meeting on UHC: Moving Together to Build Kidney Health worldwide. Retrieved 20 July 2019. https://www.theisn.org/images/ Advocacy_4_pager_2019_Final_WEB_pagebypage.pdf
  2. Foreman KJ, Marquez N, Dolgert A, et al. Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016-40 for 195 countries and territories. Lancet. 2018;392(10159):2052-90. doi: 10.1016/S0140-6736(18)31694-5
  3. Essue BM, Laba TL, Knaul F, et al. Economic burden of chronic ill health and injuries for households in low- and middle-income countries. In: Jamison DT, Gelband H, Horton S, et al., eds. Disease Control Priorities Improving Health and Reducing Poverty. 3 ed. Washington, DC: World Bank; 2018:121-43.
  4. Vanholder R, Annemans L, Brown E, et al. Reducing the costs of chronic kidney disease while delivering quality health care: a call to action. Nat Rev Nephrol. 2017;13(7):393-409. doi: 10.1038/nrneph.2017.63
  5. Luyckx VA, Tuttle KR, Garcia-Garcia G, et al. Reducing major risk factors for chronic kidney disease. Kidney Int Suppl. 2017;7(2):71-87. doi: 10.1016/j.kisu.2017.07.003
  6. Luyckx VA, Tonelli M, Stanifer JW. The global burden of kidney disease and the sustainable development goals. Bull World Health Organ. 2018;96(6):414-22D. doi: 10.2471/BLT.17.206441
  7. Tonelli M, Muntner P, Lloyd A, et al. Risk of coronary events in people with chronic kidney disease compared with those with diabetes: a population-level cohort study. Lancet. 2012;380(9844):807-14. doi: 10.1016/S0140-6736(12)60572-8
  8. Kalantar-Zadeh K, Fouque D. Nutritional Management of Chronic Kidney Disease. N Engl J Med. 2017;377(18):1765-76. doi: 10.1056/ NEJMra1700312
  9. United Nations General Assembly. Political declaration of the third high-level meeting of theGeneral Assembly on the prevention and control ofnon-communicable diseases (2018). Retrieved from https://www.un.org/ga/ search/view_doc.asp?symbol=A/73/L.2&Lang=E
  10. Lopez AD, et al. Remembering the forgotten non-communicable diseases. BMC Medicines. 2014;12(1):200. doi: 10.1186/s12916-014-0200-8
  11. (CDC) Center for Disease Control and Prevention. «Picture of America» (www.cdc.gov/pictureofamerica). At a Glance – Executive Summary. 2017;2019.
  12. Levey AS, Schoolwerth AC, Burrows NR, et al., Centers for Disease Control and Prevention Expert Panel. Comprehensive public health strategies for preventing the development, progression, and complications of CKD: report of an expert panel convened by the Centers for Disease Control and Prevention. Am J Kidney Dis. 2009;53(3):522-35. doi: 10.1053/j.ajkd.2008.11.019
  13. Saran R, Robinson B, Abbott KC, et al. US Renal Data System 2018 Annual Data Report: Epidemiology of Kidney Disease in the United States. Am J Kidney Dis. 2019;73(3S1):A7-A8. doi: 10.1053/j.ajkd. 2019.01.001
  14. Kovesdy CP, Furth SL, Zoccali C, World Kidney Day Steering Committee. Obesity and Kidney Disease: Hidden Consequences of the Epidemic. J Ren Nutr. 2017;27(2):75-7. doi: 10.4102/phcfm.v9i1.1435
  15. Tantisattamo E, Dafoe DC, Reddy UG, et al. Current Management of Acquired Solitary Kidney. Kidney Int Reports. 2019;4(9):1205-18. doi: 10.1016/j.ekir.2019.07.001
  16. Webster AC, Nagler EV, Morton RL, Masson P. Chronic Kidney Disease. Lancet. 2017;389(10075):1238-52. doi: 10.1016/S0140-6736(16)32064-5
  17. Koppe L, Fouque D. The Role for Protein Restriction in Addition to Renin-Angiotensin-Aldosterone System Inhibitors in the Management of CKD. Am J Kidney Dis. 2019;73(2):248-57. doi: 10.1053/j.ajkd.2018.06.016
  18. Rifkin DE, Coca SG, Kalantar-Zadeh K. Does AKI truly lead to CKD? J Am Soc Nephrol. 2012;23(6):979-84. doi: 10.1681/ASN.2011121185
  19. Torres VE, Chapman AB, Devuyst O, et al. Tolvaptan in patients with autosomal dominant polycystic kidney disease. N Engl J Med. 2012;367(25):2407-18. doi: 10.1056/NEJMoa1205511
  20. Verhave JC, Troyanov S, Mongeau F, et al. Prevalence, awareness, and management of CKD and cardiovascular risk factors in publicly funded health care. Clin J Am Soc Nephrol. 2014;9:7139. doi: 10.2215/CJN.06550613
  21. Chow KM, Szeto CC, Kwan B, et al. Public lacks knowledge on chronic kidney disease: Telephone survey. Hong Kong Med J. 2014;20:139-44.
  22. Ene-Iordache B, Perico N, Bikbov B, et al. Chronic kidney diseaseand cardiovascular risk in six regions of the world (ISN-KDDC): Across-sectional study. Lancet Glob Health. 2016;4:e307-19.
  23. Li PKT, Weening JJ, Dirks J, et al. A report with consensus statements of the International Society of Nephrology 2004 Consensus Workshop on Prevention of Progression of Renal Disease. Kidney Int Suppl. 2005;(94):s2-7. doi: 10.1111/j.1523-1755.2005.09401.x
  24. Vassalotti JA, Stevens LA, Levey AS. Testing for chronic kidney disease: A position statement from the National Kidney Foundation. Am J Kidney Dis. 2007;50:169-80. doi: 10.1053/j.ajkd.2007.06.013
  25. Levey AS, Atkins R, Coresh J, et al. Chronic kidney disease as a global public health problem: Approaches and initiatives – aposition statement from Kidney Disease Improving Global Outcomes. Kidney Int. 2007;72:247-59. doi: 10.1038/sj.ki.5002343
  26. Crowe E, Halpin D, Stevens P; Guideline Development Group. Early identification and management of chronic kidney disease: summary of NICE guidance. BMJ. 2008;337:a1530. doi: 10.1136/bmj.a1530
  27. Li PKT, Chow KM, Matsuo S, et al. Asian Chronic Kidney Disease (CKD) Best Practice Recommendations – Positional Statements for Early Detection of CKD from Asian Forum for CKD Initiatives (AFCKDI). Nephrology. 2011;16(7):633-41. doi: 10.1111/j.1440-1797.2011.01503.x
  28. Fink HA, Ishani A, Taylor BC, et al.: Screening for, monitoring, and treatment of chronic kidney disease stages 1 to 3: A systematic review for the U.S. Preventive Services Task Force and for an American College of Physicians Clinical Practice Guideline. Ann Intern Med. 2012;156:570-81. doi: 10.7326/0003-4819-156-8-201204170-00008
  29. Li PKT, Ng JK, Cheng YL, et al. Relatives In Silent Kidney disease Screening study (RISKS): a Chinese cohort study. Nephrology. 2017;22(Suppl. 4):35-42. doi: 10.1111/nep.13148
  30. Samal L, Linder JA. The primary care perspective on routine urine dipstick screening to identify patients with albuminuria. Clin J Am Soc Nephrol. 2013 Jan;8(1):131-5. doi: 10.2215/CJN.12681211
  31. George C, Mogueo A, Okpechi I, et al. Chronic kidney disease in low-income to middle-income countries: the case for increased screening. BMJ Glob Health. 2017;2(2):e000256. doi: 10.1136/bmjgh-2016-000256
  32. Gonzalez-Quiroz M, Nitsch D, Hamilton S, et al.; DEGREE Study Steering Committee. Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE). BMJ Open. 2019;9:e031169. doi: 10.1136/bmjopen-2019-031169
  33. Boulware LE, Jaar BG, Tarver-Carr ME, et al. Screening for proteinuria in US adults: A cost-effectiveness analysis. JAMA. 2003;290:3101-14. doi: 10.1001/jama.290.23.3101
  34. Go DS, Kim SH, Park J, et al. Cost-utility analysis of the National Health Screening Program for chronic kidney disease in Korea. Nephrology. 2019;24(1):56-64. doi: 10.1111/nep.13203
  35. Komenda P, Ferguson TW, Macdonald K, et al. Cost-effectiveness of primary screening for CKD: A systematic review. Am J Kidney Dis. 2014;63:789-97. doi: 10.1053/j.ajkd.2013.12.012
  36. Hwang SJ, Tsai JC, Chen HC. Epidemiology, impact and preventive care of chronic kidney disease in Taiwan. Nephrology. 2010;15(Suppl. 2):3-9. doi: 10.1111/j.1440-1797.2010.01304.x
  37. Almaguer M, Herrera R, Alfonso J, et al. Primary health care strategies for the prevention of end-stage renal disease in Cuba. Kidney Int Suppl. 2005;97:S4-10. doi: 10.1111/j.1523-1755.2005.09701.x
  38. Alamaguer-Lopez M, Herrera-Valdez R, Diaz J, Rodriguez O. Integration of chronic kidney disease prevention into noncommunicable disease programs in Cuba. In G. Garcia-Garcia, L.Y. Agodoa, & K.C. Norris (Eds.), Chronic Kidney Disease in Disadvantaged Populations 2017 (p. 357-65). London: Elsevier Inc.
  39. U.S. Department of Health and Human Services. Advancing American Kidney Health, 2019 accessed Sept 26, 2019. https://aspe.hhs.gov/pdf-report/advancing-american-kidney-health
  40. U.S. Department of Health and Human Services. The Special Diabetes Program for Indians. Estimates of Medicare savings, 2019. Accessed Sept 26, 2019. https://aspe.hhs.gov/pdf-report/special-diabetes-program-indians-estimates-medicare-savings
  41. Bello AK, Nwankwo E, El Nahas AM. Prevention of chronic kidney disease: a global challenge. Kidney Int Suppl. 2005;98:S11-17. doi: 10.1111/j.1523-1755.2005.09802.x
  42. James MT, Hemmelgarn BR, Tonelli M. Early recognition and prevention of chronic kidney disease. Lancet. 2010;375(9722):1296-309.
  43. Cortés-Sanabria L, Cabrera-Pivaral CE, Cueto-Manzano AM, et al. Improving care of patients with diabetes and CKD: a pilot study for a cluster-randomized trial. Am J Kidney Dis. 2008;51(5):777-88. doi: 10.1053/j.ajkd.2007.12.039
  44. Martínez-Ramírez HR, Jalomo-Martínez B, Cortés-SanabriaL, et al. Renal function preservation in type 2 diabetes mellitus patients with early nephropathy: a comparative prospective cohort study between primary health care doctors and a nephrologist. Am J Kidney Dis. 2006;47(1):78-87. doi: 10.1053/j.ajkd.2005.09.015
  45. Cueto-Manzano AM, Martínez-Ramírez HR, Cortes-Sanabria L, Rojas-Campos E. CKD screening and prevention strategies in disadvantaged populations. The role of primary health care professionals. In G. Garcia-Garcia, L.Y. Agodoa, & K.C. Norrris (Eds.), Chronic Kidney Disease in Disadvantaged Populations. 2017 (p. 329-35). London: Elsevier, Inc.
  46. Tapia-Conyer R, Gallardo-Rincon H, Betancourt-Cravioto M. Chronic kidney disease in disadvantaged populations: Online educational programs for NCD prevention and treatment. In G. Garcia-Garcia, L.Y. Agodoa, & K.C. Norris (Eds.), Chronic Kidney Disease in Disadvantaged Populations. 2017 (p. 337-45). London: Elsevier, Inc.
  47. Bello AK, Levin A, Manns BJ, et al. Effective CKD care in European countries: challenges and opportunities for health policy. Am J Kidney Dis. 2015;65(1):15-25. doi: 10.1053/j.ajkd.2014.07.033
  48. Sharif MU, Elsayed ME, Stack AG. The global nephrology workforce: emerging threats and potential solutions! Clin Kidney J. 2016;9(1):11-22. doi: 10.1093/ckj/sfv111
  49. Naicker S, Eastwood JB, Plange-Rhule J, Tutt RC. Shortage of healthcare workers in sub-Saharan Africa: a nephrological perspective. Clin Nephrol. 2010;74(Suppl. 1):S129-33.
  50. Cusumano AM, Rosa-Diez GJ, Gonzalez-Bedat MC. Latin American Dialysis and Transplant Registry: Experience and contributions to end-stage renal disease epidemiology. World J Nephrol. 2016;5(5):389-97.
  51. Feehally J, Brusselmans A, Finkelstein FO, et al. Improving global health: measuring the success of capacity building outreach programs: a view from the International Society of Nephrology. Kidney Int Suppl. 2016;6(2):42-51. doi: 10.1016/j.kisu.2016.09.002
  52. Harris DC, Dupuis S, Couser WG, Feehally J. Training nephrologists from developing countries: does it have a positive impact? Kidney Int Suppl. 2012;2(3):275-8. doi: 10.1038/kisup.2012.32
  53. Tisher CC, Bastl CP, Bistrian BR, et al. Morbidity and mortality of renal dialysis: an NIH consensus conference statement. Consensus Development Conference Panel. Ann Intern Med. 1994;121(1):62-70.
  54. Garcia-Garcia G, Martinez-Castellanos Y, Renoirte-Lopez K, et al. Multidisciplinary care for poor patients with chronic kidney disease in Mexico. Kidney Int Suppl. 2013;3(2):178-83. doi: 10.1038/kisup.2013.9
  55. Stanifer JW, Von Isenburg M, Chertow GM, Anand S. Chronic kidney disease care models in low- and middle-income countries: a systematic review. BMJ Glob Health. 2018;3(2):e000728. doi: 10.1136/bmjgh-2018-000728
  56. Narva AS, Norton JM, Boulware LE. Educating Patients about CKD: The Path to Self-Management and Patient-Centered Care. Clin J Am Soc Nephrol. 2016;11(4):694-703. doi: 10.2215/CJN.07680715
  57. Schatell D. Web-based kidney education: supporting patient self-management. Semin Dial. 2013;26(2):154-8. doi: 10.1111/sdi.12057

Supplementary files

There are no supplementary files to display.

Statistics

Views

Abstract - 86

PDF (Russian) - 11

Cited-By


PlumX

Dimensions

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
 

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Novoslobodskaya str 31c4., Moscow, 127005, Russian Federation

Managing Editor:

 

© 2018 "Consilium Medicum" Publishing house

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies