Advantages of therapy with sodium glucose cotransporter type 2 inhibitors in patients with type 2 diabetes mellitus in combination with hyperuricemia and gout

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Abstract


Currently, only two drugs for reducing uric acid (UA), allopurinol and febuxostat, are registered in the Russian Federation, but their use does not allow to achieve the target level of UA in all cases. According to the results of numerous randomized trials, hyperuricemia and gout are associated with the corresponding components of the metabolic syndrome, including diabetes mellitus. The influence of factors is due to the need to search for new drugs that have a complex effect on several components of metabolic syndrome at once. Potentially attractive in this regard is a new group of drugs for the treatment of type 2 diabetes mellitus – inhibitors of the sodium-glucose cotransporter of type 2, which, in addition to the main hypoglycemic actions, showed positive effects on the cardiovascular system, kidneys, as well as lowering UA.


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About the authors

T. S. Panevin

Nasonova Research Institute of Rheumatology; National Medical Research Center for Endocrinology

Author for correspondence.
Email: tarasel@list.ru
ORCID iD: 0000-0002-5290-156X

Russian Federation, Moscow

врач-эндокринолог; врач-ревматолог 

 

M. S. Eliseev

Nasonova Research Institute of Rheumatology

Email: tarasel@list.ru
ORCID iD: 0000-0003-1191-5831

Russian Federation, Moscow

к.м.н., ст. науч. сотр.

M. V. Shestakova

National Medical Research Center for Endocrinology

Email: tarasel@list.ru
ORCID iD: 0000-0002-5057-127X

Russian Federation, Moscow

акад. РАН, дир. Института диабета

E. L. Nasonov

Nasonova Research Institute of Rheumatology

Email: tarasel@list.ru
ORCID iD: 0000-0002-1598-8360

Russian Federation, Moscow

акад. РАН, науч. рук.

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