Mental disorders and cognitive impairment in patients with antiphospholipid syndrome

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  • Authors: Borisova A.B.1, Lisitsyna T.A.2, Veltishchev D.Y.1,3, Reshetnyak T.M.2,4, Seravina O.F.1, Kovalevskaya O.B.1, Krasnov V.N.1,3, Nasonov E.L.2
  • Affiliations:
    1. Moscow Research Institute of Psychiatry – branch of Serbskiy National Medical Research Center for Psychiatry and Addiction
    2. Nasonova Research Institute of Rheumatology
    3. Pirogov Russian National Research Medical University
    4. Russian Medical Academy of Continuous Professional Education
  • Issue: Vol 92, No 5 (2020)
  • Pages: 92-103
  • Section: Review
  • URL:
  • DOI:
  • Cite item


Mental disorders (mainly anxiety and depressive disorders) and cognitive impairment are often found in patients with antiphospholipid syndrome (APS), but their prevalence, structure, and mechanisms of occurrence are not well researched. The review provides literature data on the frequency, spectrum and possible causes of mental disorders and cognitive impairment in patients with APS, the pathogenetic mechanisms of these disorders (in particular, the important role of antiphospholipid antibodies, stress factors, chronic inflammation), the relationship between APS, mental disorders and as well as cognitive impairment is examined. Special attention is paid to the influence of mental disorders and cognitive impairment on patients’ adherence to treatment, their quality of life, as well as the particularities of psychopharmacotherapy of mental disorders in patients with APS. The aim of the review is to actualize the interdisciplinary problem of mental disorders and cognitive impairment in patients with APS and the need to introduce a partnership model of care.

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About the authors

A. B. Borisova

Moscow Research Institute of Psychiatry – branch of Serbskiy National Medical Research Center for Psychiatry and Addiction

Author for correspondence.
ORCID iD: 0000-0001-6802-0268

Russian Federation, Moscow

мл. науч. сотр. отд-ния психических расстройств при соматических заболеваниях

T. A. Lisitsyna

Nasonova Research Institute of Rheumatology

ORCID iD: 0000-0001-9437-406X

Russian Federation, Moscow

д.м.н., вед. науч. сотр. лаб. сосудистой ревматологии

D. Yu. Veltishchev

Moscow Research Institute of Psychiatry – branch of Serbskiy National Medical Research Center for Psychiatry and Addiction; Pirogov Russian National Research Medical University


Russian Federation, Moscow

д.м.н., проф. каф. психиатрии


T. M. Reshetnyak

Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuous Professional Education

ResearcherId: T-9886-2018

Russian Federation, Moscow

д.м.н., проф. каф. ревматологии; рук. лаб. сосудистой ревматологии


O. F. Seravina

Moscow Research Institute of Psychiatry – branch of Serbskiy National Medical Research Center for Psychiatry and Addiction


Russian Federation, Moscow

науч. сотр. отд-ния психических расстройств при соматических заболеваниях

O. B. Kovalevskaya

Moscow Research Institute of Psychiatry – branch of Serbskiy National Medical Research Center for Psychiatry and Addiction


Russian Federation, Moscow

науч. сотр. отд-ния психических расстройств при соматических заболеваниях

V. N. Krasnov

Moscow Research Institute of Psychiatry – branch of Serbskiy National Medical Research Center for Psychiatry and Addiction; Pirogov Russian National Research Medical University

ResearcherId: A-5117-2013

Russian Federation, Moscow

рук. отд.; зав. каф. психиатрии

E. L. Nasonov

Nasonova Research Institute of Rheumatology


Russian Federation, Moscow

науч. рук.


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