Panniculitis in modern rheumatology

Cover Page
  • Authors: Egorova O.N.1, Belov B.S.1, Glukhova S.I.1, Radenska-Lopovok S.G.2
  • Affiliations:
    1. Nasonova Research Institute of Rheumatology
    2. Sechenov First Moscow State Medical University (Sechenov University)
  • Issue: Vol 92, No 5 (2020)
  • Pages: 33-38
  • Section: Original articles
  • URL: https://ter-arkhiv.ru/0040-3660/article/view/34583
  • Cite item

Abstract


Aim. To study clinical and laboratory features of panniculitis (Pn) in modern rheumatology.

Materials and methods. The study included 690 patients with Pn (615 women and 75 men, average age – 39.4±10.26) with the prevailing referral diagnosis of Erythema nodosum (59.2%), Pn (27.5%), Rheumatic disease – Rd (9%), other diseases (4.4%),who had been on outpatient and/or inpatient treatment for 10 years. All patients were examined according to our diagnostic algorithm: general clinical, immunological and histological examinations, computed tomography of the chest organs, tuberculin tests.

Results. Pn with Rd was diagnosed in 140 patients (118 women and 22 men, average age 40.21±14.87), average disease duration 31.06 [0.1; 541] months. In most cases (49%) patients had idiopathic lobular Pn which belongs to the group of systematic lesions of connective tissue (M35.6), as well as systemic lupus erythematosus and Behcet disease (13% each), rheumatoid arthritis (8%), dermatomyositis (6.4%), etc. Matching of the referral and final diagnoses was 35% in case of Rd. Among the examined patients prevailed those with a moderate (51.07%) degree of activity of the underlying disease. Within the study group Pn was represented by all forms, but mainly by nodular form (64.02%). Mesenteric form was characteristic only for idiopathic lobular Pn. The main features of Pn associated with Rd were identified. In modern clinical practice the type of Pn and the activity of the underlying disease determine the approaches to treatment.


Full Text

Restricted Access

About the authors

O. N. Egorova

Nasonova Research Institute of Rheumatology

Author for correspondence.
Email: onegorova@yandex.ru
ORCID iD: 0000-0002-4846-5531

Russian Federation, Moscow

д.м.н., ст. науч. сотр. изучения коморбидных инфекций и мониторинга безопасности лекарственной терапии

B. S. Belov

Nasonova Research Institute of Rheumatology

Email: onegorova@yandex.ru
ORCID iD: 0000-0001-7091-2054

Russian Federation, Moscow

д.м.н., зав. лаб. изучения коморбидных инфекций и мониторинга безопасности лекарственной терапии

S. I. Glukhova

Nasonova Research Institute of Rheumatology

Email: onegorova@yandex.ru
ORCID iD: 0000-0002-4285-0869

Russian Federation, Moscow

к.ф.-м.н., ст. науч. сотр. лаб. медико-социальных проблем ревматологии

S. G. Radenska-Lopovok

Sechenov First Moscow State Medical University (Sechenov University)

Email: onegorova@yandex.ru
ORCID iD: 0000-0002-4669-260X

Russian Federation, Moscow

д.м.н., проф., проф. каф. патологической анатомии

References

  1. Вербенко Е.В. Клиника, дифференциальная диагностика и лечение спонтанного панникулита. Методические рекомендации для врачей. Под ред. Е.В. Вербенко. М., 1975; с. 18-36 [Verbenko EV. Klinika, differentsial’naya diagnostika i lechenie spontannogo pannikulita. Metodicheskie rekomendatsii [Clinic, differential diagnosis and treatment of spontaneous panniculitis. Guidelines]. Moscow, 1975:18-36 (In Russ.)]
  2. Requena L, Yus ES. Panniculitis. Part I. Mostly septal panniculitis. J Am Acad Dermatol. 2001;45(2):163-83. doi: 10.1067/mjd.2001.114736
  3. Requena L, Sanchez Yus E. Panniculitis. Part II. Mostly lobular panniculitis. J Am Acad Dermatol. 2001;45(3):325-61. doi: 10.1067/mjd.2001.114735
  4. Ter Poorten MC, Thiers BH. Panniculitis. Dermatol Clin. 2002;20(3):421-33. doi: 10.1016/S0733-8635(02)00008-6
  5. Wick MR. Panniculitis: а summary. Semin Diagn Pathol. 2017;34(3):261-72. doi: 10.1053/j.semdp.2016.12.004
  6. Егорова О.Н., Белов Б.C., Глухова С.И., Раденска-Лоповок С.Г. Идиопатический лобулярный панникулит как общеклиническая проблема. Терапевтический архив. 2019;91(5):49-53 [Egorova ON, Belov BS, Glukhova SI, Radenska-Lopovok SG. Idiopatic Lobular Panniculitis as a common clinical problem. Therapeutic Archive. 2019;91(5):49-53 (In Russ.)]. doi: 10.26442/00403660.2019.05.000187
  7. Hansen CB, Callen JP. Connective tissue panniculitis: lupus panniculitis, dermatomyositis, morphea/scleroderma. Dermatol Ther. 2010;23(4):341-9. doi: 10.1111/j.1529-8019.2010.01334.x
  8. Tibana TK, Santos RFT, Camilo DMR, et al. Mesenteric panniculitis in a patient with rheumatoid arthritis. Radiol Bras. 2019 Jul-Aug;52(4):277-8. doi: 10.1590/0100-3984.2017.0209
  9. Morita TCAB, Trés GFS, García MSC, et al. Panniculitides of particular interest to the rheumatologist. Adv Rheumatol. 2019 Aug 1;59(1):35. doi: 10.1186/s42358-019-0077-5
  10. Fornaro M, Carlino G, Abbruzzese A, et al. Symmetrical panniculitis in a patient with dermatomyositis: an unusual onset. J Clin Rheumatol. 2019 Oct 22. doi: 10.1097/RHU.0000000000001164
  11. Егорова О.Н., Белов Б.С., Раденска-Лоповок С.Г. и др. К проблеме дифференциальной диагностики панникулитов. Врач. 2014;11: 14-9 [Egorova ON, Belov BS, Radenska-Lopovok SG, et al. The problem of differential diagnosis of panniculitis. Vrach. 2014;(11):14-9 (In Russ.)].
  12. Муразян Р.И., Панченков Н.Р. Экстренная помощь при ожогах. М.: Медицина, 1983; с. 63-4 [Muresan RI, Panchenko NR. Subitis cura ardet. Moscow: Medicina, 1983:63-4 (In Russ.)].
  13. Антелава О.А., Насонов Е.Л. Современные методы оценки активности и повреждения при идиопатических воспалительных миопатиях. Научно-практическая ревматология. 2007;1:59-62 [Antela- va OA, Nasonov EL. Modern methods for assessing activity and damage in idiopathic inflammatory myopathies. Scientific and practical rheumatology. 2007;1:59-62 (In Russ.)].
  14. Kisacik B, Onat AM, Pehlivan Y. Multiclinical experiences in erythema nodosum: rheumatology clinics versus dermatology and infection diseases clinics. Rheumatol Int. 2013;33(2):315-8. doi: 10.1007/s00296-012-2413-5
  15. Papagrigoraki A. Erythema nodosum: etiological factors and relapses in a retrospective cohort study. Eur J Dermatol. 2010;20(6):773-7. doi: 10.1684/ejd.2010.1116
  16. Mangold AR, Costello CM, Cumsky HJL, et al. Systemic scleroderma and lupus panniculitis with atypical clinical features: a case report and comprehensive review. JAAD Case Rep. 2018;4(8):789-93. doi: 10.1016/j.jdcr.2018.03.022
  17. Stiefelhagen P. Even in fever, joint pain and erythema: Borrelia antibodies do not prove Lyme disease. MMW Fortschr Med. 2006;148(11):14.
  18. Алекберова З.С., Голоева З.С., Елонаков А.В. Болезнь Бехчета у детей. Рус. мед. журн. 2006;14(25):1783-5 [Alekberova ZS, Goloe- va ZS, Elonakov AV. Behcet’s disease in children. Rus Med J. 2006;14 (25):1783-5 (In Russ.)].
  19. Takase H, Shimizu T. Erythema nodosum-like lesion on heel in a patient assumed Behçet’s disease. BMJ Case Rep. 2019;12(11). pii: e232056. doi: 10.1136/bcr-2019-232056
  20. Alpsoy E, Zouboulis CC, Ehrlich GE. Mucocutaneous lesions of Behcet’s disease. Yonsei Med J. 2007;48(4):573-85.
  21. Atienza-Mateo B, Calvo-Río V, Beltrán E, et al. Anti-interleukin 6 receptor tocilizumab in refractory uveitis associated with Behçet’s disease: multicentre retrospective study. Rheumatology (Oxford). 2018;57(5):856-64. doi: 10.1093/rheumatology/kex480
  22. Ugurlu N, Bozkurt S, Bacanli А. The natural course and factors affecting severity of Behçet’s disease: a single-center cohort of 368 patients. Rheumatol Int. 2015;35(12):2103-7. doi: 10.1007/s00296-015-3310-5
  23. Васильев В.И., Логвиненко О.А., Симонова М.В. и др. Развитие сухого синдрома при саркоидозе с поражением слюнных желез. Терапевтический архив. 2005;77(1):62-7 [Vasil’ev VI, Logvinenko OA, Simonova MV, et al. Razvitie sukhogo sindroma prisarkoidoze s porazheniem slyunnykh i sleznykh zhelez. Therapeutic Archive. 2005;77(1):62-7 (In Russ.)].
  24. Седышев С.Х., Васильев В.И. Саркоидоз в практике ревматолога. Рос. мед. журн. 2009;3:156-9 [Sedyshev SKh, Vasiliev V.I. Sarcoidosis in the practice of a rheumatologist. Rus Med J. 2009;3:156-9 (In Russ.)].
  25. Shioya N, Kojika М, Endoet S. Multiple transverse colonic perforations associated with slow-release nonsteroidal anti-inflammatory drugs and corticosteroids: a case report. Case Reports Critical Care. 2011; Article ID: 824639:4. doi: 10.1155/2011/824639
  26. Yamamoto T, Yokoyama A, Yamamoto Y, Mamada A. Erythema nodosum associated with Sjögren’s syndrome. Br J Rheumatol. 1997;36(6):707-8.

Statistics

Views

Abstract - 7

PDF (Russian) - 11

Cited-By


Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
 

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Novoslobodskaya str 31c4., Moscow, 127005, Russian Federation

Managing Editor:

 

© 2018 "Consilium Medicum" Publishing house

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies