The molecular marker of the preconditioning phenomenon HIF1α is a new pathway for early detection of visceral hypoxic conditions

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Abstract


Improvement and development of technologies for laboratory and instrumental examination of patients in recent years have greatly facilitated the diagnosis of ischemic myocardial damage. However, a decrease in the rating of cardiovascular diseases is not expected in the short term. This is due to an increase in the life expectancy of the population, general aging of the population and improving diagnostic capabilities and the provision of medical care. The time for verification of the diagnosis of ischemic disease, simplified the decision on treatment tactics were significantly reduced by introduction of X-ray contrast visualization examination methods such as angiography, quantitative and qualitative laboratory tests, development of diagnostic criteria based on the results of ultrasound and electrophysiological examination methods. Unfortunately, all these techniques are secondary in nature and are applied, when organ damage is for the most part already irreversible. Full restoration of organs is possible only if the patient is successfully evacuated to the hospital and there are specialists of the appropriate level of experiebce, X-ray surgical equipment with suitable supplies or pharmacological agents, usefull for quickly restoration the patency of the great vessels and normal blood flow. A large number of studies appear on the phenomenon of preconditioning at the present stage of development of fundamental medical science. The purpose of this article is to reveal the possibilities of using molecular markers of the phenomenon of preconditioning in the framework of the early detection of hypoxic conditions, the assessment of their diagnostic use in the clinic and the prevention of hypoxia-associated diseases.


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About the authors

D. V. Cherkashin

Kirov Military Medical Academy

Author for correspondence.
Email: cherkashin_dmitr@mail.ru
ORCID iD: 0000-0003-1363-6860

Russian Federation, Saint Petersburg

д.м.н., нач. каф. военно-морской терапии

A. V. Lyubimov

Kirov Military Medical Academy

Email: cherkashin_dmitr@mail.ru
ORCID iD: 0000-0001-9829-4681

Russian Federation, Saint Petersburg

к.м.н., ст. ординатор каф. военно-морской терапии

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Supplementary files

Supplementary Files Action
1.
Change in HIF1α protein concentration before and after exposure to a stress factor.

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