Evaluation of the effectiveness of ultrasound shear elastography and liver steatometry

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Abstract


Detection of liver fibrosis and steatosis at early stages is a difficult task for clinical practice, due to the lack of early signs in routine radiation diagnostics.

Aim. To evaluate the efficacy of ultrasound shear elastography and ultrasound steatometry of the liver with the use of domestic ultrasonic diagnostic system Angiodin-Sono/N-Ultra.

Materials and methods. 264 people held ultrasound elastography and ultrasound steatometry. 38 patients underwent percutaneous puncture liver biopsy and subsequent pathophysiological examination.

Results. High correlation of fibrosis obtained at the Angiodin-Sono/N-Ultra and the leading ultrasonic systems with shear elastography was revealed. Cross-sectional comparative analysis of elasticity with the results of liver steatometry was conducted.

Conclusions. Results obtained in all groups correlate with the data obtained in studies on Fibroscan. When working with system Angiodin we got a simultaneous comparative analysis of elasticity with the results of liver steatosis. Results appear to be much more stable and compact than those obtained in studies on the Fibroscan. A new diagnostic criterion was revealed – the phenomenon of independence of fibrosis and steatosis indices.


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About the authors

O. I. Tarasova

Рeoples’ Friendship University of Russia

Author for correspondence.
Email: tarasova_oi@pfur.ru
ORCID iD: 0000-0001-6376-8189

Russian Federation, Moscow

доц. каф. госпитальной терапии Центра изучения печени

E. I. Kuhareva

Рeoples’ Friendship University of Russia

Email: tarasova_oi@pfur.ru
ORCID iD: 0000-0001-6538-9027

Russian Federation, Moscow

ассистент каф. госпитальной терапии Центра изучения печени

S. K. Krasnitskaya

Рeoples’ Friendship University of Russia

Email: tarasova_oi@pfur.ru
ORCID iD: 0000-0003-1618-0942

Russian Federation, Moscow

морфолог, Центр изучения печени

N. V. Mazurchik

Рeoples’ Friendship University of Russia

Email: tarasova_oi@pfur.ru
ORCID iD: 0000-0002-2524-9203

Russian Federation, Moscow

доцент каф. госпитальной терапии Центра изучения печени

M. Ya. Ngameni

Рeoples’ Friendship University of Russia

Email: tarasova_oi@pfur.ru
ORCID iD: 0000-0001-7230-3711

Russian Federation, Moscow

аспирант каф. госпитальной терапии Центра изучения печени

N. A. Malinina

Рeoples’ Friendship University of Russia

Email: tarasova_oi@pfur.ru
ORCID iD: 0000-0002-0829-474X

Russian Federation, Moscow

аспирант каф. госпитальной терапии Центра изучения печени

B. I. Zykin

Рeoples’ Friendship University of Russia

Email: tarasova_oi@pfur.ru
ORCID iD: 0000-0002-8871-1434

Russian Federation, Moscow

проф. каф. госпитальной терапии Центра изучения печени

P. P. Ogurtsov

Рeoples’ Friendship University of Russia

Email: tarasova_oi@pfur.ru
ORCID iD: 0000-0001-7939-891X

Russian Federation, Moscow

проф., зав. каф. госпитальной терапии Центра изучения печени

References

  1. Ивашкин В.Т., Маевская М.В., Павлов Ч.С., Тихонов И.Н. Клинические рекомендации по диагностике и лечению неалкогольной жировой болезни печени Российского общества по изучению печени и Российской гастроэнтерологической ассоциации. Рос. журн. гастроэнтерологии, гепатологии, колопроктологии. 2016;2:24-42 [Ivashkin VT, Maevskaya MV, Pavlov ChS, Tihonov IN. Klinicheskie rekomendacii po diagnostike i lecheniyu nealkogol’noj zhirovoj bolezni pecheni Rossijskogo obshchestva po izucheniyu pecheni i Rossijskoj gastroenterologicheskoj associacii. Ros. zhurn. gastroenterologii, gepatologii, koloproktologii. 2016;2:24-42 (In Russ.)]. doi: 10.22416/1382-4376-2016-26-2-24-42
  2. Целиковский А.В., Притулина Ю.Г., Астапченко Д.С. и др. Влияние стеатоза печени на эффективность комбинированной противовирусной терапии хронического гепатита С. Современные проблемы науки и образования. 2012;6:186 [Celikovskij AV, Pritulina YuG, Astapchenko DS, et al. Vliyanie steatoza pecheni na effektivnost’ kombinirovannoj protivovirusnoj terapii hronicheskogo gepatita S. Sovremennye problemy nauki i obrazovaniya. 2012;6:186 (In Russ.)].
  3. Chan H, Wong G, Choi PC, et al. Alanine aminotransferase-based algorithms of liver stiffness measurement by transient elastography (Fibroscan) for liver fibrosis in chronic hepatitis B. J Viral Hepat. 2009;16(1):36-44. doi: 10.1111/j.1365-2893.2008.01037.x
  4. Castera L, Vilgrain V, Anguo P. Nonivasive evaluation of NAFLD. Nat Rev Gastroenterol Hepatol. 2013;10:666-75. doi: 10.1038/ nrgastro.2013.175 PMID: 24061203
  5. Бакулин И.Г., Сандлер Ю.Г., Кейян В.А., Ротин Д.Л. Новый неинвазивный метод оценки стеатоза при хронических заболеваниях печени. Терапевтический архив. 2016;88(2):49-57 [Bakulin IG, Sandler YuG, Kejyan VA, Rotin DL. Novyj neinvazivnyj metod ocenki steatoza pri hronicheskih zabolevaniyah pecheni. Therapeutic Archive. 2016;88(2):49-57 (In Russ.)]. doi: 10.17116/terarkh201688249-57
  6. Castera L, Vergniol J, Foucher J et al. Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C. Gastroenterology. 2005;128(2):343-50. doi: 10.1053/j.gastro.2004.11.018
  7. Bedossa P. Current histological classification of NAFLD: strength and limitations. Hepatol Int. 2013;7(2):765-70. doi: 10.1007/s12072-013-9446-z
  8. Leung VY, Shen J, Wong VW, et al. Quantitative elastography of liver fibrosis and spleen stiffness in chronic hepatitis B carriers: comparison of shearwave elastography and transient elastography with liver biopsy correlation. Radiology. 2013;269:910-8. doi: 10.1148/radiol.13130128
  9. Herrmann E, de Lédinghen V, Cassinotto C, et al. Assessment of biopsyproven liver fibrosis by two-dimensional shear wave elastography: An individual patient data-based meta-analysis. Hepatology. 2018;67:260-72. doi: 10.1002/hep.29179
  10. Wong VW, Vergniol J, Wong GL, et al. Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology. 2010;51:454-62. doi: 10.1002/hep.23312
  11. Castera L, Foucher J, Bernard PH, et al. Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations. Hepatology. 2010;51:828-35. doi: 10.1002/hep.23425
  12. Sporea I, Jurchiş A, Şirli R, et al. Can Transient Elastography be a reliable method for assessing liver fibrosis in Non Alcoholic Steatohepatitis (NASH)? Med Ultrason. 2013;15(2):106-10. doi: 10.11152/mu. 2013.2066.152.is1aj2
  13. Mulabecirovic A, Mjelle AB, Gilja OH, et al. Liver elasticity in healthy individuals by two novel shear-wave elastography systems – Comparison by age, gender, BMI and number of measurements. PloS one. 2018;13(9):art.no.e0203486. doi: 10.1371/journal.pone.0203486
  14. Zeng J, Zheng J, Huang Z, et al. Comparison of 2-D Shear Wave Elastography and Transient Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B. Ultrasound Med Biol. 2017;43:1563-70. doi: 10.1016/j.ultrasmedbio.2017.03.014
  15. Wu T, Wang P, Zhang T, et al. Comparison of Two-Dimensional Shear Wave Elastography and Real-Time Tissue Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B. Dig Dis. 2016;34:640-9. doi: 10.1159/000448825
  16. Zhuang Y, Ding H, Zhang Y, et al. Twodimensional Shear-Wave Elastography Performance in the Noninvasive Evaluation of Liver Fibrosis in Patients with Chronic Hepatitis B: Comparison with Serum Fibrosis Indexes. Radiology. 2017;283:873-82. doi: 10.1148/radiol.2016160131
  17. De Lédinghen V, Vergniol J, Foucher J, et al. Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography. Liver Int. 2012;32(6):911-8. doi: 10.1111/j.1478-3231.2012.02820
  18. Kosasih S, Zhi Qin W, Abdul Rani R, et al. Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease. Int J Hepatol. 2018:9252536. doi: 10.1155/2018/9252536

Supplementary files

Supplementary Files Action
1.
Comparison of the results of liver elastometry in the control group.

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