Laboratory diagnostics in medicine

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The development of clinical laboratory diagnostics is in line with the evidence-based medicine, which requires that clinical decisions have to be based on diagnostic methods with proven informativity. This creates a request for the scientific validity of the use of laboratory researches and application of probabilistic interpretation tools corresponding to the tasks. The concept of indefiniteness (analytical, biological and clinical) is at the heart of interpretation of laboratory results. The inclusion of laboratory research in clinical guidelines, the choice and appointment of this research to the patient should not be made from the position of ideas about increasing or decreasing the laboratory index in the disease, but on the basis of its scientifically proven characteristics as a laboratory biomarker – sensitivity, specificity, predictive value, as well as the relationship with certain clinical events, outcomes, risks. These characteristics are probabilistic and can be defined.

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About the authors

A. G. Kochetov

National Medical Research Center for Cardiology; Institute of Laboratory Medicine; People’s Friendship University of Russia

Author for correspondence.
ORCID iD: 0000-0003-3632-291X

Russian Federation, Moscow

рук. отд. лабораторной диагностики; ректор; д.м.н., проф. каф. госпитальной терапии с курсом клинической лабораторной диагностики

O. V. Lyang

Institute of Laboratory Medicine; People’s Friendship University of Russia; Federal Center for Cerebrovascular Pathology and Stroke

ORCID iD: 0000-0002-1023-5490

Russian Federation, Moscow

проректор по учебной работе; д.м.н., доц. каф. госпитальной терапии с курсом клинической лабораторной диагностики; зав. отд-нием клинической лабораторной диагностики

I. A. Zhirova

People’s Friendship University of Russia

ORCID iD: 0000-0002-6621-2052

Russian Federation, Moscow

к.м.н., доц. каф. госпитальной терапии с курсом клинической лабораторной диагностики

O. O. Ivoilov

National Medical Research Center for Cardiology; People’s Friendship University of Russia

ORCID iD: 0000-0002-4684-8440

Russian Federation, Moscow

к.м.н., ст. науч. сотр. отд. лабораторной диагностики; ассистент каф. госпитальной терапии с курсом клинической лабораторной диагностики


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