10-year risk of fractures (FRAX) in people with diabetes type 2

  • Authors: Mazurenko ES1,2, Malutina SK2, Shcherbakova LV2, Hrapova Y.V1, Isaeva MP3, Rymar OD3
  • Affiliations:
    1. Tsivyan Novosibirsk Research Institute of Traumatology and Orthopaedics
    2. Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
    3. Novosibirsk State University
  • Issue: Vol 91, No 10 (2019)
  • Pages: 76-81
  • Section: Editorial
  • URL: https://ter-arkhiv.ru/0040-3660/article/view/33703
  • DOI: https://doi.org/10.26442/00403660.2019.10.000113
  • Cite item


Aim. To study indicators of bone mineral densit (BMD) and trabecular bone score (TBS) and to reveal the 10-year fracture risk (FRAX®) taking into account the data obtained in persons with type 2 diabetes (DM2). Materials and methods. A clinical study of the type of case - control. The study included 122 people with and without DM2. All persons were: questionnaires, anthropometry, densitometry, determination of TBS and fracture risk on the FRAX®. Results and discussion. Persons with DM2 who underwent a fracture had lower T-score values in all areas except the spine, unlike those with DM2, but without fracture. However, persons with DM2 had a fracture at high values of T-score in vertebrae and hips in comparison with persons without DM. Using the TBS, we did not get a significant difference in any of the examined groups. We also found no differences in the risk of recurrent fractures among women with and without DM2 using FRAX® without densitometry and FRAX® adjusted for TBS. The values of FRAX® by T-score in the group of persons with DM with fractures were significantly lower (p=0.029 for major fractures, p=0.024 for hip fractures) than in persons without DM with fractures. Conclusion. Persons with DM2 and fractures have higher BMD values, lower than the FRAX fracture risk values adjusted for the T-score, do not differ significantly in TBS, which determines the difficulties in diagnosis, the need to find additional methods for early diagnosis of increased fracture risk in patients with DM2.

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About the authors

E S Mazurenko

Tsivyan Novosibirsk Research Institute of Traumatology and Orthopaedics; Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Email: poltorackayaes@gmail.com
Novosibirsk, Russia

S K Malutina

Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Novosibirsk, Russia

L V Shcherbakova

Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Novosibirsk, Russia

Yu V Hrapova

Tsivyan Novosibirsk Research Institute of Traumatology and Orthopaedics

Novosibirsk, Russia

M P Isaeva

Novosibirsk State University

Novosibirsk, Russia

O D Rymar

Novosibirsk State University

Novosibirsk, Russia


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