Email this article Incidence and characteristics of complications in aplastic anemia patients treated with antilymphocytic globulin
- Authors: Ganapiev AA1, Abdulkadyrov KM1, Afanasyev BV1
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Affiliations:
- Issue: Vol 78, No 8 (2003)
- Pages: 68-72
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/33393
- ID: 33393
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Abstract
Aim. To examine frequency and characteristic features of complications arising in administration of
domestic antilymphocytic globulin (ALG) in patients with aplastic anemia (AA).
Material and methods. From 1980 to 2000 125patients with AA were treated with ALG made in Russia.
Two and three courses of ALG were performed in 25 and 8 patients, respectively.
Results. The treatment was complicated most often with allergic reactions (AR) observed in 42.4% patients,
hemorrhagic syndrome (HS) and infectious complications (1С). Goat ALG was more allergic
than rabbit ALG (46.2 vs 34.6%, respectively). If the second course was made with ALG of the same
kind, AR occurred in 37.5% patients while ALG of the different kind produced complications only in
11.8% patients. HS was recorded in 37.3% patients , its frequency was unrelated to ALG kind and
was not severe (71.2%). 1С occurred in 16.5% patients, their occurrence was also unrelated to the
ALG kind and were of the first degree in 63.6%.
Conclusion. Domestic ALG often results in AR. To reduce frequency and severity of complications in
ALG treatment, it is recommended to use long intravenous infusions (12-18 h) and change ALG kind
in subsequent ALG courses.
domestic antilymphocytic globulin (ALG) in patients with aplastic anemia (AA).
Material and methods. From 1980 to 2000 125patients with AA were treated with ALG made in Russia.
Two and three courses of ALG were performed in 25 and 8 patients, respectively.
Results. The treatment was complicated most often with allergic reactions (AR) observed in 42.4% patients,
hemorrhagic syndrome (HS) and infectious complications (1С). Goat ALG was more allergic
than rabbit ALG (46.2 vs 34.6%, respectively). If the second course was made with ALG of the same
kind, AR occurred in 37.5% patients while ALG of the different kind produced complications only in
11.8% patients. HS was recorded in 37.3% patients , its frequency was unrelated to ALG kind and
was not severe (71.2%). 1С occurred in 16.5% patients, their occurrence was also unrelated to the
ALG kind and were of the first degree in 63.6%.
Conclusion. Domestic ALG often results in AR. To reduce frequency and severity of complications in
ALG treatment, it is recommended to use long intravenous infusions (12-18 h) and change ALG kind
in subsequent ALG courses.
References
- Абдулкадыров К. М., Шабапин В. Н., Серова Л. Д. и др. Лечение больных гипопластической анемией пересадками костного мозга с применением антилимфоцитарного глобулина. Вестн. АМН СССР 1973; 6: 69-73.
- Mathe G., Amiel J., Schwarzenberg J. et al. Bone marrow grafts in man after conditioning by antilymphocyte globulin. Br. Med. J. 1970; 12 (2): 131-136.
- Camitta В., Thomas E. D., Nathan D. G. et al. Severe aplastic anemia. A prospective study on the effect of early marrow transplantation on acute mortality. Blood 1976; 48(5): 65-67.
- Miller A. B. WHO recommendations for grading of acute and subacute toxicity. Cancer (Philad.) 1981; 47 (8): 210-211.
- Bielory L., Gascon P., Yancey К. В. et al. Human serum sickness after equine antithymocyte globulin in patients with bone marrow failure. Medicine (Baltimore) 1988; 67 (4): 40-52.
- Young N. S., Griffith P., Brittain E. et al. A multicenter trial of antithymocyte globulin in aplastic anaemia and related diseases. Blood 1988; 72 (6): 1861-1869
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